J
Jeffrey L. Halaas
Researcher at Rockefeller University
Publications - 14
Citations - 17432
Jeffrey L. Halaas is an academic researcher from Rockefeller University. The author has contributed to research in topics: Leptin receptor & Leptin. The author has an hindex of 12, co-authored 14 publications receiving 16975 citations. Previous affiliations of Jeffrey L. Halaas include Howard Hughes Medical Institute.
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Journal ArticleDOI
Leptin and the regulation of body weight in mammals
TL;DR: The role of leptin in the control of body weight and its relevance to the pathogenesis of obesity are reviewed.
Journal ArticleDOI
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Jeffrey L. Halaas,Gajiwala Ketan,Margherita Maffei,Steven L. Cohen,Brian T. Chait,Daniel Rabinowitz,Roger Lallone,Stephen K. Burley,Jeffrey M. Friedman +8 more
TL;DR: Injection of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent, suggesting that the OB protein serves an endocrine function to regulate body fat stores.
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Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Margherita Maffei,Jeffrey L. Halaas,Eric Ravussin,Richard E. Pratley,Gwo-Hwa Lee,Gwo-Hwa Lee,Yan Zhang,Yan Zhang,Hong Fei,S. Kim,R. Lallone,S. Ranganathan,Philip A. Kern,Philip A. Kern,Jeffrey M. Friedman,Jeffrey M. Friedman +15 more
TL;DR: Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans, suggesting differences in its secretion rate from fat.
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Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
Christian Vaisse,Jeffrey L. Halaas,Curt M. Horvath,James E. Darnell,Markus Stoffel,Jeffrey M. Friedman +5 more
TL;DR: The data indicate the hypothalamus is a direct target of leptin action and that this activation is critically dependent on the gp-130-like leptin receptor isoform missing in C57BLKS/J db/db mice, the first in vivo demonstration of leptin signal transduction.
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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
Jeffrey L. Halaas,Carol Boozer,J. R. Blair-West,Naseem Fidahusein,Derek A. Denton,Jeffrey M. Friedman +5 more
TL;DR: The decreased response to leptin in diet-induced obese, NZO, and Ay mice suggests that obesity in these strains is the result of leptin resistance, which probably results from defects downstream of the leptin receptor in the hypothalamus.