H
Hong Jiang
Researcher at Central South University
Publications - 393
Citations - 23057
Hong Jiang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 51, co-authored 280 publications receiving 18722 citations. Previous affiliations of Hong Jiang include University of Texas at Austin & City University of New York.
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Journal ArticleDOI
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
Alexandre Reuben,Christine N. Spencer,Peter A. Prieto,Vancheswaran Gopalakrishnan,Sangeetha M. Reddy,John P. Miller,Xizeng Mao,Mariana Petaccia de Macedo,Jiong Chen,Xingzhi Song,Hong Jiang,Pei Ling Chen,Hannah C. Beird,Haven R. Garber,Whijae Roh,Khalida Wani,Eveline Chen,Cara Haymaker,Marie Andrée Forget,Latasha Little,Curtis Gumbs,Rebecca Thornton,Courtney W. Hudgens,Wei Shen Chen,Jacob Austin-Breneman,Robert Sloane,Luigi Nezi,Alexandria P. Cogdill,Chantale Bernatchez,Jason Roszik,Patrick Hwu,Scott E. Woodman,Lynda Chin,Hussein Abdul-Hassan Tawbi,Michael A. Davies,Jeffrey E. Gershenwald,Rodabe N. Amaria,Isabella C. Glitza,Adi Diab,Sapna Pradyuman Patel,Jianhua Hu,Jeffrey E. Lee,Elizabeth A. Grimm,Michael T. Tetzlaff,Alexander J. Lazar,Ignacio I. Wistuba,Karen Clise-Dwyer,Brett W. Carter,Jianhua Zhang,P. Andrew Futreal,Padmanee Sharma,James P. Allison,Zachary A. Cooper,Zachary A. Cooper,Jennifer A. Wargo +54 more
TL;DR: The authors emphasize the importance of acquiring biopsies from more than one tumor site in order to best tailor therapies to the features of metastatic cancer, and have key translational implications in the age of precision medicine.
Journal ArticleDOI
The RB-E2F1 Pathway Regulates Autophagy
Hong Jiang,Vanesa Martin,Candelaria Gomez-Manzano,David G. Johnson,Marta M. Alonso,Erin J. White,Jing Xu,Timothy J. McDonnell,Naoki Shinojima,Juan Fueyo +9 more
TL;DR: The findings indicate that RB induces autophagy by repressing E2F1 activity, and it is speculated that this newly discovered aspect of RB function is relevant to cancer development and therapy.
Journal Article
Benzo (a) pyrene diol epoxide – induced chromosomal aberrations and risk of lung cancer
TL;DR: The characteristics of chromosomal aberrations induced in vitro by activated benzo(a)pyrene diol epoxide (BPDE) in lymphocyte cultures of 172 normal individuals and the analysis of a pilot case-control study of lung cancer patients and 96 selected controls without history of cancer are described.
Journal ArticleDOI
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death
Marta M. Alonso,Hong Jiang,Tomohisa Yokoyama,Jing Xu,Nebiyou Bekele,Frederick F. Lang,Seiji Kondo,Candelaria Gomez-Manzano,Juan Fueyo +8 more
TL;DR: This is the first report showing that Delta-24-RGD plus RAD001 causes autophagic cell death, and dramatically increases long-term survival rates of glioma-bearing animals, and synergistically enhanced by combination with RAD001.
Human adenovirus type 5 induces cell lysis through autophagy and
Hong Jiang,Erin J. White,Christian I. Ríos-Vicil,Jing Xu,Candelaria Gomez-Manzano,Juan Fueyo +5 more
TL;DR: This study implicates autophagy and caspase activation as part of the mechanism for cell lysis induced by adenovirus and suggests that manipulation of the process is a potential strategy to optimize clinical efficacy of oncolyticAdenoviruses.