E
Elizabeth A. Grimm
Researcher at University of Texas MD Anderson Cancer Center
Publications - 247
Citations - 17620
Elizabeth A. Grimm is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Melanoma & Cytotoxic T cell. The author has an hindex of 65, co-authored 241 publications receiving 16582 citations. Previous affiliations of Elizabeth A. Grimm include Children's Hospital of Philadelphia & University of Texas System.
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Journal ArticleDOI
Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.
TL;DR: Evidence is presented that the LAK system is a phenomenon distinct from either NK or CTL systems that probably accounts for a large number of reported nonclassical cytotoxicities and may be functional in immune surveillance against human solid tumors.
Journal ArticleDOI
Biological activity of recombinant human interleukin-2 produced in Escherichia coli
Steven A. Rosenberg,Elizabeth A. Grimm,Michael Mcgrogan,Michael Doyle,Ernest S. Kawasaki,Kirston E. Koths,David F. Mark +6 more
TL;DR: The recombinant lymphokine supports the growth of murine and human interleukin-2 dependent cell lines, enhances the generation of cytolytic cells in vitro and in vivo after alloimmunization, and generates lymphokin activated killer cells from murineand human lymphocytes.
Journal ArticleDOI
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
A. Gordon Robertson,Juliann Shih,Juliann Shih,Christina Yau,Ewan A. Gibb,Junna Oba,Karen Mungall,Julian M. Hess,Vladislav Uzunangelov,Vonn Walter,Vonn Walter,Ludmila Danilova,Tara M. Lichtenberg,Melanie H. Kucherlapati,Patrick K. Kimes,Ming Tang,Alexander V Penson,Özgün Babur,Rehan Akbani,Christopher A. Bristow,Katherine A. Hoadley,Lisa Iype,Matthew T. Chang,Matthew T. Chang,Mohamed H. Abdel-Rahman,Adrian Ally,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Christopher C. Benz,Rameen Beroukhim,Inanc Birol,Tom Bodenheimer,Jay Bowen,Reanne Bowlby,Denise Brooks,Rebecca Carlsen,Colleen M. Cebulla,Andrew D. Cherniack,Andrew D. Cherniack,Lynda Chin,Juok Cho,Eric Chuah,Sudha Chudamani,Carrie Cibulskis,Kristian Cibulskis,Leslie Cope,Sarah E. Coupland,Timothy Defreitas,John A. Demchok,Laurence Desjardins,Noreen Dhalla,Bita Esmaeli,Ina Felau,Martin L. Ferguson,Scott Frazer,Stacey Gabriel,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Jeffrey E. Gershenwald,Gad Getz,Klaus G. Griewank,Elizabeth A. Grimm,D. Neil Hayes,Apurva M. Hegde,David I. Heiman,Carmen Helsel,Shital Hobensack,Robert A. Holt,Alan P. Hoyle,Xin Hu,Carolyn M. Hutter,Martine J. Jager,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Cyriac Kandoth,Katayoon Kasaian,Jaegil Kim,Raju Kucherlapati,Eric S. Lander,Michael S. Lawrence,Alexander J. Lazar,Semin Lee,Kristen M. Leraas,Pei Lin,Jia Liu,Wen-Bin Liu,Laxmi Lolla,Yiling Lu,Yussanne Ma,Harshad S. Mahadeshwar,Odette Mariani,Marco A. Marra,Michael Mayo,Sam Meier,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Gordon B. Mills,Richard A. Moore,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Rashi Naresh,Michael S. Noble,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Joel S. Parker,Charles M. Perou,Todd Pihl,Robert Pilarski,Alexei Protopopov,Amie Radenbaugh,Karan Rai,Nilsa C. Ramirez,Xiaojia Ren,Sheila Reynolds,Jeffrey Roach,Sergio Roman-Roman,Jason Roszik,Sara Sadeghi,Gordon Saksena,Xavier Sastre,Dirk Schadendorf,Jacqueline E. Schein,Lynn Schoenfield,Steven E. Schumacher,Jonathan G. Seidman,Sahil Seth,Geetika Sethi,Margi Sheth,Yan Shi,Carol L. Shields,Ilya Shmulevich,Janae V. Simons,Arun D. Singh,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Marc-Henri Stern,Joshua M. Stuart,Qiang Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Barry S. Taylor,Nina Thiessen,Vesteinn Thorsson,Kane Tse,Umadevi Veluvolu,Roel G.W. Verhaak,Doug Voet,Yunhu Wan,Zhining Wang,John N. Weinstein,Matthew D. Wilkerson,Michelle D. Williams,Lisa Wise,Scott E. Woodman,Tina Wong,Ye Wu,Liming Yang,Lixing Yang,Jean C. Zenklusen,Jiashan Zhang,Hailei Zhang,Erik Zmuda +173 more
TL;DR: Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.
Journal ArticleDOI
The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
S. Farzana Hussain,David J. Yang,Dima Suki,Kenneth Aldape,Elizabeth A. Grimm,Amy B. Heimberger +5 more
TL;DR: The immune performance and interactions of CNS microglia/macrophages in glioma patients were studied in this article, where the authors found that microglias were the predominant immune cell infiltrating gliomas (~ 1% of total cells); others identified were myeloid dendritic cells (DCs), plasmacytoid DCs, and T cells.
Journal Article
Induction of Chemosensitivity in Human Lung Cancer Cells in Vivo by Adenovirus-mediated Transfer of the Wild-Type p53 Gene
Toshiyoshi Fujiwara,Elizabeth A. Grimm,Tapas Mukhopadhyay,Wei-Wei Zhang,Laurie B. Owen-Schaub,Jack A. Roth +5 more
TL;DR: Results support the clinical application of a regimen combining gene replacement using replication-deficient wild-type p53 adenovirus and DNA-damaging drugs for treatment of human cancer.