H
Hong Jiang
Researcher at Central South University
Publications - 393
Citations - 23057
Hong Jiang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 51, co-authored 280 publications receiving 18722 citations. Previous affiliations of Hong Jiang include University of Texas at Austin & City University of New York.
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Journal ArticleDOI
Expression of Transcription Factor E2F1 and Telomerase in Glioblastomas: Mechanistic Linkage and Prognostic Significance
Marta M. Alonso,Juan Fueyo,Jerry W. Shay,Kenneth Aldape,Hong Jiang,Ok Hee Lee,David G. Johnson,Jing Xu,Yasuko Kondo,Takao Kanzawa,Satoru Kyo,B. Nebiyou Bekele,Xian Zhou,Janice Nigro,J. Matthew McDonald,W. K. Alfred Yung,Candelaria Gomez-Manzano +16 more
TL;DR: E2F1 may participate in telomerase activity regulation in malignant glioma cells and its expression appears to be strongly associated with the survival of patients with malignant brain tumors.
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ICOVIR-5 Shows E2F1 Addiction and Potent Antiglioma Effect In vivo
Marta M. Alonso,Manel Cascallo,Candelaria Gomez-Manzano,Hong Jiang,B. Nebiyou Bekele,Anna Perez-Gimenez,Frederick F. Lang,Yuji Piao,Ramon Alemany,Juan Fueyo +9 more
TL;DR: The antitumor activity of ICOVIR-5 suggests that it has the potential to be an effective agent in the treatment of gliomas and shows for the first time the ability of oncolytic adenoviruses to enhance E2F transcriptional activity in vivo.
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Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4
TL;DR: Two independent preclinical trials with valproic acid (VPA), a promising therapeutic HDAC inhibitor, found that VPA could both increase the acetylation levels of hist one H3 and histone H4 and reduce the early apoptotic rate of cells without inhibiting the aggregation of mutant ataxin-3 proteins in MJDtr-Q68- expressing cells.
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Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer
Sangeetha M. Reddy,Sangeetha M. Reddy,Alexandre Reuben,Souptik Barua,Souptik Barua,Hong Jiang,Shaojun Zhang,Linghua Wang,Vancheswaran Gopalakrishnan,Courtney W. Hudgens,Michael T. Tetzlaff,James M. Reuben,James M. Reuben,Takahiro Tsujikawa,Takahiro Tsujikawa,Lisa M. Coussens,Khalida Wani,Yan He,Lily Villareal,Anita Wood,Arvind Rao,Wendy A. Woodward,Wendy A. Woodward,Naoto T. Ueno,Naoto T. Ueno,Savitri Krishnamurthy,Savitri Krishnamurthy,Jennifer A. Wargo,Elizabeth A. Mittendorf,Elizabeth A. Mittendorf +29 more
TL;DR: The results highlight the strong association of mast cell infiltration with poor response to NAC, suggesting a mechanism of treatment resistance and a potential therapeutic target in IBC.
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Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo.
Marta M. Alonso,Candelaria Gomez-Manzano,Hong Jiang,Nebiyou Bekele,Yuji Piao,W. K. A. Yung,Ramon Alemany,Juan Fueyo +7 more
TL;DR: Combination of ICOVIR-5 with RAD001 or TMZ showed a potent anti-glioma effect in vivo, resulting in a dramatic extension of the median animal survival and in 20–40% animals becoming free of disease beyond 90 days.