H
Hong Wang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 30
Citations - 1849
Hong Wang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & PTEN. The author has an hindex of 18, co-authored 30 publications receiving 1562 citations. Previous affiliations of Hong Wang include Zhejiang University & Cornell University.
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Journal ArticleDOI
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Katrina Podsypanina,Richard T. Lee,Chris Politis,Ian Hennessy,Allison Crane,Janusz Puc,Mehran S. Neshat,Hong Wang,Lin Yang,Jay Gibbons,Phil Frost,Valley C. Dreisbach,John Blenis,Zbigniew Gaciong,Peter E. Fisher,Charles L. Sawyers,Lora Hedrick-Ellenson,Ramon Parsons +17 more
TL;DR: It is shown that transformed cells of PTEN+/− mice have elevated levels of phosphorylated Akt and activated p70/S6 kinase associated with an increase in proliferation and that inhibition of these proteins may be therapeutic for cancer patients with deranged PI3K signaling.
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Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome
Satyendra C. Tripathi,Haley L. Peters,Ayumu Taguchi,Hiroyuki Katayama,Hong Wang,Amin Momin,Mohit Kumar Jolly,Muge Celiktas,Jaime Rodriguez-Canales,Hui Liu,Carmen Behrens,Ignacio I. Wistuba,Eshel Ben-Jacob,Herbert Levine,Jeffrey J. Molldrem,Samir M. Hanash,Edwin J. Ostrin +16 more
TL;DR: It is demonstrated for the first time to the authors' knowledge that lung cancer cells that have undergone epithelial-to-mesenchymal transition lose immunoproteasome expression, resulting in markedly reduced antigen presentation, and a strategy to overcome immune evasion through induction of the immunoproteinasome to increase the cellular repertoire of HLA class I-bound peptides is suggested.
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Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity.
Michela Capello,Jody Vykoukal,Hiroyuki Katayama,Leonidas E. Bantis,Leonidas E. Bantis,Hong Wang,Deepali L. Kundnani,Clemente Aguilar-Bonavides,Mitzi Aguilar,Satyendra C. Tripathi,Dilsher Dhillon,Amin Momin,Haley L. Peters,Matthew H.G. Katz,Héctor M. Alvarez,Vincent Bernard,Sammy Ferri-Borgogno,Randall E. Brand,Douglas G. Adler,Matthew A. Firpo,Sean J. Mulvihill,Jeffrey J. Molldrem,Ziding Feng,Ayumu Taguchi,Anirban Maitra,Samir M. Hanash +25 more
TL;DR: Evidence is provided that exosomes display a large repertoire of tumor antigens that induce autoantibodies and exert a decoy function against complement-mediated cytotoxicity against cancer cells.
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Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer.
Michela Capello,Leonidas E. Bantis,Ghislaine Scelo,Yang Zhao,Peng Li,Dilsher Dhillon,Nikul Patel,Deepali L. Kundnani,Hong Wang,James L. Abbruzzese,Anirban Maitra,Margaret A. Tempero,Randall E. Brand,Matthew A. Firpo,Sean J. Mulvihill,Matthew H.G. Katz,Paul Brennan,Ziding Feng,Ayumu Taguchi,Samir M. Hanash +19 more
TL;DR: The addition of TIMP1 and LRG1 immunoassays to CA19-9 statistically significantly improves the detection of early-stage PDAC.
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Akt-Mediated Phosphorylation and Activation of Estrogen Receptor α Is Required for Endometrial Neoplastic Transformation in Pten+/− Mice
Anna E. Vilgelm,Zenglin Lian,Hong Wang,Stephen L. Beauparlant,Andres J. Klein-Szanto,Lora Hedrick Ellenson,Antonio Di Cristofano +6 more
TL;DR: In vivo evidence is provided supporting the hypothesis that loss of Pten and subsequent Akt activation result in the activation of ERalpha-dependent pathways that play a pivotal role in the neoplastic process.