H
Hongwei Si
Researcher at Tennessee State University
Publications - 34
Citations - 1904
Hongwei Si is an academic researcher from Tennessee State University. The author has contributed to research in topics: Genistein & Monocyte. The author has an hindex of 19, co-authored 28 publications receiving 1516 citations. Previous affiliations of Hongwei Si include Virginia Tech.
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Journal ArticleDOI
Genistein Acutely Stimulates Insulin Secretion in Pancreatic β-Cells Through a cAMP-Dependent Protein Kinase Pathway
TL;DR: It is demonstrated that genistein directly acts on pancreatic beta-cells, leading to activation of the cAMP/PKA signaling cascade to exert an insulinotropic effect, thereby providing a novel role of soy isoflavones in the regulation of insulin secretion.
Journal ArticleDOI
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival
Hongwei Si,Dongmin Liu +1 more
TL;DR: Several recently identified potential antiaging phytochemicals that have been studied in cells, animals and humans are reviewed and the cellular and molecular mechanisms underlying the antiaging actions by these molecules are highlighted.
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Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets.
TL;DR: Findings suggest that ABA could be used as a nutritional intervention against type II diabetes and obesity-related inflammation.
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Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IΚBα/NF-κB signaling pathway
Zhenquan Jia,Palanisamy Nallasamy,Dongmin Liu,Halley Shah,Jason Z. Li,Rojin Chitrakar,Hongwei Si,John McCormick,Hong Zhu,Wei Zhen,Yunbo Li,Yunbo Li +11 more
TL;DR: It is reported that luteolin as low as 0.5 μM significantly inhibited tumor necrosis factor (TNF)-α-induced adhesion of monocytes to human EA and preserved elastin fibers' delicate organization as shown by Verhoeff-Van Gieson staining.
Journal ArticleDOI
Genistein, a Soy Phytoestrogen, Upregulates the Expression of Human Endothelial Nitric Oxide Synthase and Lowers Blood Pressure in Spontaneously Hypertensive Rats
Hongwei Si,Dongmin Liu +1 more
TL;DR: The data suggest that genistein has direct genomic effects on the vascular wall that are unrelated to its known actions, leading to increased eNOS expression and NO synthesis, thereby improving hypertension.