Journal ArticleDOI
Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets.
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TLDR
Findings suggest that ABA could be used as a nutritional intervention against type II diabetes and obesity-related inflammation.About:
This article is published in Clinical Nutrition.The article was published on 2007-02-01. It has received 143 citations till now. The article focuses on the topics: Glucose homeostasis & Glucose tolerance test.read more
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An Update on Abscisic Acid Signaling in Plants and More
Aleksandra Wasilewska,Florina Vlad,Caroline Sirichandra,Yulia Redko,Fabien Jammes,Christiane Valon,Nicolas Frei dit Frey,Jeffrey Leung +7 more
TL;DR: Undoubtedly, the most astonishing revelation is that ABA is not restricted to plants and mosses, but overwhelming evidence now indicates that it also exists in metazoans ranging from the most primitive to the most advance on the evolution scale (sponges to humans).
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Dietary phytochemicals and their potential effects on obesity: a review.
TL;DR: The progresses made in understanding of obesity are summarized, including the role of inflammation process, the recently understood endocrine function of adipose tissue, as well as passive roles of processes of energy storage and adipogenesis related to fat cell lifecycle: differentiation, maturation, and apoptosis.
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Amorfrutins are potent antidiabetic dietary natural products
Christopher Weidner,Jens C. de Groot,Aman Prasad,Anja Freiwald,Claudia Quedenau,Magdalena Kliem,Annabell Witzke,Vitam Kodelja,Chung-Ting Han,Sascha Giegold,Matthias Baumann,Bert Klebl,Karsten Siems,Lutz Müller-Kuhrt,Annette Schürmann,Rita Schüler,Andreas Pfeiffer,Frank C. Schroeder,Konrad Büssow,Sascha Sauer +19 more
TL;DR: In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity.
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Water shortage and quality of fleshy fruits—making the most of the unavoidable
TL;DR: An up-to-date review of current knowledge of the effects of different forms of drought on fruit quality relative to the primary and secondary metabolisms and their interactions focuses on fruit crops owing to the importance of secondary metabolism in fruit quality and the importance in the human diet.
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Natural anti-obesity agents
TL;DR: The anti-obesity potential of natural products is discussed and multiple-natural product combinations may result in a synergistic activity that increases their bioavailability and action on multiple molecular targets, offering advantages over chemical treatments.
References
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
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Inflammation, stress, and diabetes
TL;DR: The molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes are discussed.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Béatrice Desvergne,Walter Wahli +1 more
TL;DR: This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.