Wei Zhen

TL;DR: It is demonstrated that genistein directly acts on pancreatic beta-cells, leading to activation of the cAMP/PKA signaling cascade to exert an insulinotropic effect, thereby providing a novel role of soy isoflavones in the regulation of insulin secretion.

TL;DR: Dietary intake of genistein significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in streptozotocin-induced diabetic mice, concomitant with improved islet beta-cell proliferation, survival, and mass, demonstrating that geniste in may be a natural antidiabetic agent by directly modulating pancreatic beta- cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway.

TL;DR: It is reported that luteolin as low as 0.5 μM significantly inhibited tumor necrosis factor (TNF)-α-induced adhesion of monocytes to human EA and preserved elastin fibers' delicate organization as shown by Verhoeff-Van Gieson staining.

TL;DR: Findings provide the first evidence that DHEA acts as a survival factor for endothelial cells by triggering the Galphai-PI3K/Akt-Bcl-2 pathway to protect cells against apoptosis.

TL;DR: It is demonstrated that kaempferol may be a naturally occurring anti-diabetic agent by improving peripheral insulin sensitivity and protecting against pancreatic β-cell dysfunction by improving hyperglycemia, glucose tolerance, and blood insulin levels in obese diabetic mice.