H
Hongwei Si
Researcher at Tennessee State University
Publications - 34
Citations - 1904
Hongwei Si is an academic researcher from Tennessee State University. The author has contributed to research in topics: Genistein & Monocyte. The author has an hindex of 19, co-authored 28 publications receiving 1516 citations. Previous affiliations of Hongwei Si include Virginia Tech.
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Journal ArticleDOI
Phytochemical Genistein in the Regulation of Vascular Function: New Insights
Hongwei Si,Dongmin Liu +1 more
TL;DR: The novel roles for genistein in the regulation of vascular function are revealed and provide a basis for further investigating its therapeutic potential for inflammatory-related vascular disease.
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Dehydroepiandrosterone Protects Vascular Endothelial Cells against Apoptosis through a Gαi Protein-Dependent Activation of Phosphatidylinositol 3-Kinase/Akt and Regulation of Antiapoptotic Bcl-2 Expression
TL;DR: Findings provide the first evidence that DHEA acts as a survival factor for endothelial cells by triggering the Galphai-PI3K/Akt-Bcl-2 pathway to protect cells against apoptosis.
Journal ArticleDOI
Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
Hongwei Si,Zhuo Fu,Pon Velayutham Anandh Babu,Wei Zhen,Tanya LeRoith,Mary Pat Meaney,Kevin A. Voelker,Zhenquan Jia,Robert W. Grange,Dongmin Liu +9 more
TL;DR: Pathological analysis showed that epicatechin administration reduced the degeneration of aortic vessels and blunted fat deposition and hydropic degeneration in the liver caused by diabetes, and may be a novel food-derived, antiaging compound.
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Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue
Amir J. Guri,Raquel Hontecillas,Gerardo Ferrer,Oriol Casagran,Umesh D. Wankhade,Alexis M Noble,Decio L. Eizirik,Fernanda Ortis,Miriam Cnop,Dongmin Liu,Hongwei Si,Josep Bassaganya-Riera +11 more
TL;DR: Molecular evidence in vivo is provided demonstrating that ABA improves insulin sensitivity and obesity-related inflammation by inhibiting MCP-1 expression and F4/80(hi) ATM infiltration through a PPARgamma-dependent mechanism.
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Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals.
TL;DR: Five mechanisms are proposed including enhancing the bioavailability of phytochemicals, increasing antioxidant capacity, interacting with gut microbiome and targeting same and different signaling pathways, to understand how the combination of phyllochemicals exerts synergistic anti-inflammatory effects in cells, animals, and humans.