H
Hugo Fernandes
Researcher at University of Coimbra
Publications - 54
Citations - 2568
Hugo Fernandes is an academic researcher from University of Coimbra. The author has contributed to research in topics: Mesenchymal stem cell & Tissue engineering. The author has an hindex of 19, co-authored 49 publications receiving 2074 citations. Previous affiliations of Hugo Fernandes include Maastricht University & University of Twente.
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Journal ArticleDOI
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
Huipin Yuan,Hugo Fernandes,Pamela Habibovic,Jan de Boer,Ana M.C. Barradas,Ad de Ruiter,William R. Walsh,Clemens van Blitterswijk,Joost D. de Bruijn +8 more
TL;DR: Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts, providing proof of concept for the clinical application of “smart” biomaterials.
Journal ArticleDOI
A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.
Ana M.C. Barradas,Hugo Fernandes,Nathalie Groen,Yoke Chin Chai,Jan Schrooten,Jeroen van de Peppel,Johannes P.T.M. van Leeuwen,Clemens van Blitterswijk,Jan de Boer +8 more
TL;DR: It is demonstrated that hMSC osteogenesis can be induced via extracellular Ca(2+), a simple and economic way of priming hMSCs for bone tissue engineering applications.
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Native and bioengineered extracellular vesicles for cardiovascular therapeutics
Ricardo Cerqueira de Abreu,Ricardo Cerqueira de Abreu,Hugo Fernandes,Paula A. da Costa Martins,Susmita Sahoo,Costanza Emanueli,Lino Ferreira +6 more
TL;DR: Vesicles secreted from stem or progenitor cells and from differentiated somatic cells have regenerative properties in the context of myocardial infarction, ischaemic limb disease and stroke.
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Endothelial Differentiation of Mesenchymal Stromal Cells
Karolina Janeczek Portalska,Anne Marijke Leferink,Nathalie Groen,Hugo Fernandes,Lorenzo Moroni,Clemens van Blitterswijk,Jan de Boer +6 more
TL;DR: A robust protocol for endothelial differentiation of hMSCs is established, including an immortalized MSC line (iMSCs) which allows for reproducible in vitro analysis in further studies.
Journal ArticleDOI
Growth, metabolism, and growth inhibitors of mesenchymal stem cells
Deborah Schop,Frank Janssen,Linda van Rijn,Hugo Fernandes,Rolf M. Bloem,Joost D. de Bruijn,Riemke van Dijkhuizen-Radersma +6 more
TL;DR: Goat MSCs grew significantly faster than human and rat M SCs and that goat cells metabolized glucose more efficiently into energy and glutamine was shown not to be important as energy source for human, goat, and ratMSCs.