J
Jeroen van de Peppel
Researcher at Erasmus University Medical Center
Publications - 53
Citations - 2511
Jeroen van de Peppel is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Mesenchymal stem cell & Osteoblast. The author has an hindex of 19, co-authored 45 publications receiving 2080 citations. Previous affiliations of Jeroen van de Peppel include Utrecht University & University Medical Center Utrecht.
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Journal ArticleDOI
A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.
Ana M.C. Barradas,Hugo Fernandes,Nathalie Groen,Yoke Chin Chai,Jan Schrooten,Jeroen van de Peppel,Johannes P.T.M. van Leeuwen,Clemens van Blitterswijk,Jan de Boer +8 more
TL;DR: It is demonstrated that hMSC osteogenesis can be induced via extracellular Ca(2+), a simple and economic way of priming hMSCs for bone tissue engineering applications.
Journal ArticleDOI
Mediator Expression Profiling Epistasis Reveals a Signal Transduction Pathway with Antagonistic Submodules and Highly Specific Downstream Targets
Jeroen van de Peppel,Nienke Kettelarij,Harm van Bakel,Thessa T. J. P. Kockelkorn,Dik van Leenen,Frank C. P. Holstege +5 more
TL;DR: Findings support a role for Mediator as a direct processor of signaling pathways for determining specificity, and subtle modification of the general transcription machinery through one of its own components is shown to determine highly specific expression patterns.
Journal ArticleDOI
Monitoring global messenger RNA changes in externally controlled microarray experiments
Jeroen van de Peppel,Patrick Kemmeren,Harm van Bakel,Marijana Radonjic,Dik van Leenen,Frank C. P. Holstege +5 more
TL;DR: The levels of most mRNAs were found to change during yeast stationary phase and human heat shock when external controls were included, and this suggests that global mRNA changes occur more frequently than is assumed at present.
Journal ArticleDOI
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Carolina Medina-Gomez,John P. Kemp,John P. Kemp,Katerina Trajanoska,Jian'an Luan,Alessandra Chesi,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Dennis O. Mook-Kanamori,Annelies C. Ham,Fernando Pires Hartwig,Daniel S. Evans,Raimo Joro,Ivana Nedeljkovic,Hou-Feng Zheng,Hou-Feng Zheng,Hou-Feng Zheng,Kun Zhu,Kun Zhu,Mustafa Atalay,Ching-Ti Liu,Maria Nethander,Linda Broer,Gudmar Porleifsson,Benjamin H. Mullin,Benjamin H. Mullin,Samuel K. Handelman,Mike A. Nalls,Leon Eyrich Jessen,Denise H. M. Heppe,J. Brent Richards,Carol A. Wang,Bo L. Chawes,Katharina E. Schraut,Najaf Amin,Nicholas J. Wareham,David Karasik,Nathalie van der Velde,Nathalie van der Velde,M. Arfan Ikram,Babette S. Zemel,Yanhua Zhou,Christian J. Carlsson,Yongmei Liu,Fiona E. McGuigan,Cindy G. Boer,Klaus Bønnelykke,Stuart H. Ralston,John A Robbins,John P. Walsh,John P. Walsh,M. Carola Zillikens,Claudia Langenberg,Ruifang Li-Gao,Frances M K Williams,Tamara B. Harris,Kristina Åkesson,Rebecca D. Jackson,Gunnar Sigurdsson,Martin den Heijer,Martin den Heijer,Bram C. J. van der Eerden,Jeroen van de Peppel,Tim D. Spector,Craig E. Pennell,Bernardo L. Horta,Janine F. Felix,Jing Hua Zhao,Scott Wilson,Scott Wilson,Scott Wilson,Renée de Mutsert,Hans Bisgaard,Unnur Styrkarsdottir,Vincent W. V. Jaddoe,Eric S. Orwoll,Timo A. Lakka,Robert A. Scott,Struan F.A. Grant,Mattias Lorentzon,Cornelia M. van Duijn,James F. Wilson,Kari Stefansson,Bruce M. Psaty,Bruce M. Psaty,Douglas P. Kiel,Claes Ohlsson,Evangelia E. Ntzani,Andre J. van Wijnen,Vincenzo Forgetta,Mohsen Ghanbari,Mohsen Ghanbari,John G. Logan,Graham R. Williams,J. H. Duncan Bassett,Peter I. Croucher,Evangelos Evangelou,Evangelos Evangelou,André G. Uitterlinden,Cheryl L. Ackert-Bicknell,Jonathan H Tobias,David M. Evans,David M. Evans,Fernando Rivadeneira +103 more
TL;DR: TB-BMD is revealed as a relevant trait for genetic studies of osteoporosis, enabling the identification of variants and pathways influencing different bone compartments and their effect can be captured throughout the life course.
Journal ArticleDOI
MicroRNA functions in osteogenesis and dysfunctions in osteoporosis.
Andre J. van Wijnen,Jeroen van de Peppel,Johannes P.T.M. van Leeuwen,Jane B. Lian,Gary S. Stein,Jennifer J. Westendorf,Merry Jo Oursler,Hee Jeong Im,Hanna Taipaleenmäki,Eric Hesse,Scott M. Riester,Sanjeev Kakar +11 more
TL;DR: This overview examines key principles by which miRNAs control differentiation of osteoblasts as they evolve from mesenchymal stromal cells during osteogenesis, or of osteoclast as they originate from monocytic precursors in the hematopoietic lineage during osteoclastogenesis.