H
Hugues A. Girard
Researcher at École Polytechnique
Publications - 68
Citations - 2560
Hugues A. Girard is an academic researcher from École Polytechnique. The author has contributed to research in topics: Diamond & Nanoparticle. The author has an hindex of 28, co-authored 65 publications receiving 2293 citations. Previous affiliations of Hugues A. Girard include Commissariat à l'énergie atomique et aux énergies alternatives & Versailles Saint-Quentin-en-Yvelines University.
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Journal ArticleDOI
Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells.
Orestis Faklaris,Vandana Joshi,Theano Irinopoulou,Patrick Tauc,Mohamed Sennour,Hugues A. Girard,Céline Gesset,Jean-Charles Arnault,Alain Thorel,Jean-Paul Boudou,Patrick A. Curmi,François Treussart +11 more
TL;DR: It is shown that nanodiamonds enter cells mainly by endocytosis, and converging data indicate that it is clathrin-mediated, and the results pave the way for the use of photoluminescent nanod diamonds in targeted intracellular labeling or biomolecule delivery.
Journal ArticleDOI
Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells
Orestis Faklaris,Vandana Joshi,Theano Irinopoulou,Patrick Tauc,Hugues A. Girard,Céline Gesset,Mohamed Senour,Alain Thorel,Jean-Charles Arnault,Jean-Paul Boudou,Patrick A. Curmi,François Treussart +11 more
TL;DR: In this article, the authors used photoluminescent nanodiamonds of size <50 nm for intracellular labeling and investigated the mechanism of their uptake by living cells, by blocking selectively different uptake processes and converging data indicate that it is clathrin mediated.
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Surface properties of hydrogenated nanodiamonds: a chemical investigation.
Hugues A. Girard,Tristan Petit,Sandrine Perruchas,Thierry Gacoin,Céline Gesset,Jean-Charles Arnault,Philippe Bergonzo +6 more
TL;DR: The chemical reactivity of fully hydrogenated High Pressure High Temperature (HPHT) nanodiamonds (H-NDs) towards grafting is reported, suggesting that C-H related surface properties remain dominant even on particles at the nanoscale.
Journal ArticleDOI
Early stages of surface graphitization on nanodiamond probed by x-ray photoelectron spectroscopy
TL;DR: In this paper, the early stages of graphitization on detonation nanodiamond during sequential annealing treatments under vacuum using x-ray photoelectron spectroscopy were investigated.
Journal ArticleDOI
Carboxylated nanodiamonds are neither cytotoxic nor genotoxic on liver, kidney, intestine and lung human cell lines
Vincent Paget,Jacques-Aurélien Sergent,Romain Grall,Sandrine Altmeyer-Morel,Hugues A. Girard,Tristan Petit,Céline Gesset,Michel Mermoux,Philippe Bergonzo,Jean-Charles Arnault,Sylvie Chevillard +10 more
TL;DR: Overall, it is shown that NDs effectively entered the cells but NDs do not induce any significant cytotoxic or genotoxic effects on the six cell lines up to an exposure dose of 250 µg/mL.