H
Hui Guo
Researcher at Chinese Academy of Sciences
Publications - 39
Citations - 1644
Hui Guo is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Minimum inhibitory concentration & Ulocladium. The author has an hindex of 21, co-authored 38 publications receiving 1263 citations. Previous affiliations of Hui Guo include University of Science and Technology of China.
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Journal ArticleDOI
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
Michael B. Harbut,Catherine Vilchèze,Xiaozhou Luo,Mary E. Hensler,Hui Guo,Baiyuan Yang,Arnab Chatterjee,Victor Nizet,William R. Jacobs,Peter G. Schultz,Feng Wang +10 more
TL;DR: The results suggest that the thioredoxin-mediated redox cascade of Gram-positive pathogens is a valid target for the development of antibacterial drugs, and that the existing clinical agent auranofin may be repurposed to aid in the treatment of several important antibiotic-resistant pathogens.
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Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: natural thioether Michael addition adducts as antitubercular prodrugs.
Qian Wang,Fuhang Song,Xue Xiao,Pei Huang,Li Li,Aaron Monte,Wael M. Abdel-Mageed,Wael M. Abdel-Mageed,Jian Wang,Hui Guo,Wenni He,Feng Xie,Huanqin Dai,Miaomiao Liu,Caixia Chen,Hao Xu,Mei Liu,Andrew M. Piggott,Xueting Liu,Robert J. Capon,Lixin Zhang +20 more
TL;DR: The current shortfall in antitubercular drugs demands urgent attention, to develop new antibiotics effective against all strains of tuberculosis.
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Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.
Xiaozhou Luo,Guangsen Fu,Rongsheng E. Wang,Xueyong Zhu,Claudio Zambaldo,Renhe Liu,Tao Liu,Xiaoxuan Lyu,Jintang Du,Weimin Xuan,Anzhi Yao,Sean A. Reed,Mingchao Kang,Yuhan Zhang,Hui Guo,Chunhui Huang,Peng-Yu Yang,Ian A. Wilson,Peter G. Schultz,Feng Wang +19 more
TL;DR: This work has identified an orthogonal aminoacyl-tRNA synthetase/tRNA pair that allows the site-specific incorporation of both pTyr and Pmp into recombinant proteins in response to the amber stop codon in Escherichia coli in good yields.
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Brevianamides with Antitubercular Potential from a Marine-Derived Isolate of Aspergillus versicolor
Fuhang Song,Xinru Liu,Hui Guo,Biao Ren,Caixia Chen,Andrew M. Piggott,Yu Ke,Hong Gao,Qian Wang,Mei Liu,Xueting Liu,Huanqin Dai,Lixin Zhang,Robert J. Capon +13 more
TL;DR: Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S, suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.
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Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.
Quan-Xin Wang,Li Bao,Xiao-Li Yang,Hui Guo,Ruinan Yang,Biao Ren,Lixin Zhang,Lixin Zhang,Huanqin Dai,Liangdong Guo,Hongwei Liu +10 more
TL;DR: Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-Hydroxy-8-methoxy-3a-methyl-3A,9b-dihydro-3H-furo[3,2-c] isochromene-2,5-dione (2), along with eleven known compounds, were isolated from the culture of the endolichen