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Xueyong Zhu
Researcher at Scripps Research Institute
Publications - 129
Citations - 10547
Xueyong Zhu is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Epitope & Hemagglutinin (influenza). The author has an hindex of 44, co-authored 125 publications receiving 7707 citations. Previous affiliations of Xueyong Zhu include University of Science and Technology of China & Wuhan University.
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Journal ArticleDOI
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.
Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Ray T.Y. So,Huibin Lv,Chris Ka Pun Mok,Ian A. Wilson +7 more
TL;DR: The crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein at 3.1-angstrom resolution is determined, providing molecular insights into antibody recognition of Sars-Cov-2.
Journal ArticleDOI
New world bats harbor diverse influenza A viruses.
Suxiang Tong,Xueyong Zhu,Yan Li,Mang Shi,Jing Zhang,Melissa Bourgeois,Hua Yang,Xianfeng Chen,Sergio Recuenco,Jorge Gomez,Li-Mei Chen,Adam Johnson,Ying Tao,C. Dreyfus,Wenli Yu,Ryan McBride,Paul J. Carney,Amy T. Gilbert,Jessie Chang,Zhu Guo,Charles T. Davis,James C. Paulson,James Stevens,Charles E. Rupprecht,Charles E. Rupprecht,Edward C. Holmes,Edward C. Holmes,Ian A. Wilson,Ruben O. Donis +28 more
TL;DR: Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
Journal ArticleDOI
Structural basis of a shared antibody response to SARS-CoV-2.
Meng Yuan,Hejun Liu,Nicholas C. Wu,Chang-Chun D Lee,Xueyong Zhu,Fangzhu Zhao,Deli Huang,Wenli Yu,Yuanzi Hua,Henry Tien,Thomas F. Rogers,Thomas F. Rogers,Elise Landais,Elise Landais,Devin Sok,Devin Sok,Joseph G. Jardine,Joseph G. Jardine,Dennis R. Burton,Ian A. Wilson +19 more
TL;DR: It is found that immunoglobulin G heavy-chain variable region 3-53 (IGHV3-53) is the most frequently used IGHV gene for targeting the receptor-binding domain (RBD) of the spike protein, which is promising for vaccine design.
Journal ArticleDOI
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen.
Antonietta Impagliazzo,Fin Milder,Harmjan Kuipers,Michelle Wagner,Xueyong Zhu,Ryan M. B. Hoffman,Ruud van Meersbergen,Jeroen Huizingh,Patrick Wanningen,Johan Verspuij,Martijn de Man,Zhaoqing Ding,Adrian Apetri,Başak Kükrer,Eveline Sneekes-Vriese,Danuta Tomkiewicz,Nick S. Laursen,Peter Lee,Anna Zakrzewska,Liesbeth Dekking,Jeroen Tolboom,Lisanne Tettero,Sander van Meerten,Wenli Yu,Wouter Koudstaal,Jaap Goudsmit,Andrew B. Ward,Wim Meijberg,Ian A. Wilson,Katarina Radosevic +29 more
TL;DR: The results represent a proof of concept for the design of HA stem mimics that elicit bnAbs against influenza A group 1 viruses and completely protects mice in lethal heterologous and heterosubtypic challenge models, and reduces fever after sublethal challenge in cynomolgus monkeys.
Posted ContentDOI
A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV
Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Ray T.Y. So,Huibin Lv,Chris Ka Pun Mok,Ian A. Wilson +7 more
TL;DR: The crystal structure of the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein in complex with CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient is determined.