H
Huichen Feng
Researcher at University of Pittsburgh
Publications - 38
Citations - 6547
Huichen Feng is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Merkel cell polyomavirus & Cell culture. The author has an hindex of 26, co-authored 35 publications receiving 6083 citations. Previous affiliations of Huichen Feng include University of Hong Kong.
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Journal ArticleDOI
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TL;DR: In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
Journal ArticleDOI
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
Masahiro Shuda,Huichen Feng,Hyun Jin Kwun,Steven T. Rosen,Ole Gjoerup,Patrick S. Moore,Yuan Chang,Yuan Chang +7 more
TL;DR: It is shown that tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by LT but do eliminate viral DNA replication capacity, suggesting that MCV-positive MCC tumor cells undergo selection for LT mutations to prevent autoactivation of integrated virus replication that would be detrimental to cell survival.
Journal ArticleDOI
Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens
Roland Houben,Masahiro Shuda,Rita Weinkam,David Schrama,Huichen Feng,Yuan Chang,Patrick S. Moore,J. C. Becker +7 more
TL;DR: This study provides the first direct experimental evidence that TA expression is necessary for the maintenance of MCV-positive MCC and that MCV is the infectious cause ofMCV- positive MCC.
Journal ArticleDOI
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.
Masahiro Shuda,Reety Arora,Hyun Jin Kwun,Huichen Feng,Ronit Sarid,María Teresa Fernández-Figueras,Yanis L. Tolstov,Ole Gjoerup,Mahesh Mansukhani,Steven H. Swerdlow,Preet M. Chaudhary,John M. Kirkwood,Michael A. Nalesnik,Jeffrey A. Kant,Lawrence M. Weiss,Patrick S. Moore,Yuan Chang +16 more
TL;DR: A monoclonal antibody is developed that specifically recognizes endogenous and transfected MCV large T (LT) antigen and expression of this putative viral oncoprotein in tumor cells provides the mechanistic underpinning supporting the notion that MCV causes a subset of MCC.
Journal ArticleDOI
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
TL;DR: It is shown that MCV small T (sT) antigen is expressed in most MCC tumors, where it is required for tumor cell growth and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers.