M
Mahesh Mansukhani
Researcher at Columbia University
Publications - 105
Citations - 5952
Mahesh Mansukhani is an academic researcher from Columbia University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 35, co-authored 95 publications receiving 5447 citations. Previous affiliations of Mahesh Mansukhani include Columbia University Medical Center & NewYork–Presbyterian Hospital.
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Journal ArticleDOI
PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
Lao H. Saal,Karolina Holm,Matthew Maurer,Lorenzo Memeo,Tao Su,Xiaomei Wang,Jennifer S. Yu,Per-Uno Malmström,Mahesh Mansukhani,Jens Enoksson,Hanina Hibshoosh,Åke Borg,Ramon Parsons +12 more
TL;DR: Mutation of PIK3CA is frequent, occurs early in carcinoma development, and has prognostic and therapeutic implications and the association between ERBB2 overexpression and Pik3CA mutation implies that more than one input activating the PI3K/AKT pathway may be required to overcome intact PTEN.
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Diagnostic Assay Based on hsa-miR-205 Expression Distinguishes Squamous From Nonsquamous Non–Small-Cell Lung Carcinoma
Danit Lebanony,Hila Benjamin,Shlomit Gilad,Meital Ezagouri,Avital Dov,Karin Ashkenazi,Nir Gefen,Shai Izraeli,Gideon Rechavi,Harvey I. Pass,Daisuke Nonaka,Junjie Li,Yael Spector,Nitzan Rosenfeld,Ayelet Chajut,Dalia Cohen,Ranit Aharonov,Mahesh Mansukhani +17 more
TL;DR: The standardized diagnostic assay presented here can provide highly accurate subclassification of NSCLC patients and identify hsa-miR-205 as a highly specific marker for squamous cell lung carcinoma.
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Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.
Masahiro Shuda,Reety Arora,Hyun Jin Kwun,Huichen Feng,Ronit Sarid,María Teresa Fernández-Figueras,Yanis L. Tolstov,Ole Gjoerup,Mahesh Mansukhani,Steven H. Swerdlow,Preet M. Chaudhary,John M. Kirkwood,Michael A. Nalesnik,Jeffrey A. Kant,Lawrence M. Weiss,Patrick S. Moore,Yuan Chang +16 more
TL;DR: A monoclonal antibody is developed that specifically recognizes endogenous and transfected MCV large T (LT) antigen and expression of this putative viral oncoprotein in tumor cells provides the mechanistic underpinning supporting the notion that MCV causes a subset of MCC.
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Lack of PTEN sequesters CHK1 and initiates genetic instability
Janusz Puc,Megan Keniry,Hong Shen Li,Tej K. Pandita,Atish D. Choudhury,Lorenzo Memeo,Mahesh Mansukhani,Vundavalli V. Murty,Zbigniew Gaciong,Sarah E. M. Meek,Helen Piwnica-Worms,Hanina Hibshoosh,Ramon Parsons +12 more
TL;DR: It is concluded that loss of PTEN and subsequent activation of AKT impair CHK1 through phosphorylation, ubiquitination, and reduced nuclear localization to promote genomic instability in tumor cells.
Journal ArticleDOI
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations
Xuewen Liu,Yuxia Jia,Mark B. Stoopler,Yufeng Shen,Haiying Cheng,Jinli Chen,Mahesh Mansukhani,Sanjay Koul,Balazs Halmos,Alain C. Borczuk +9 more
TL;DR: Mutational events of MET leading to exon 14 skipping are frequent and potentially targetable events in PSC.