R
Reety Arora
Researcher at National Centre for Biological Sciences
Publications - 21
Citations - 1118
Reety Arora is an academic researcher from National Centre for Biological Sciences. The author has contributed to research in topics: Merkel cell polyomavirus & Merkel cell carcinoma. The author has an hindex of 10, co-authored 20 publications receiving 990 citations. Previous affiliations of Reety Arora include University of Pittsburgh & Tata Institute of Fundamental Research.
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Journal ArticleDOI
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.
Masahiro Shuda,Reety Arora,Hyun Jin Kwun,Huichen Feng,Ronit Sarid,María Teresa Fernández-Figueras,Yanis L. Tolstov,Ole Gjoerup,Mahesh Mansukhani,Steven H. Swerdlow,Preet M. Chaudhary,John M. Kirkwood,Michael A. Nalesnik,Jeffrey A. Kant,Lawrence M. Weiss,Patrick S. Moore,Yuan Chang +16 more
TL;DR: A monoclonal antibody is developed that specifically recognizes endogenous and transfected MCV large T (LT) antigen and expression of this putative viral oncoprotein in tumor cells provides the mechanistic underpinning supporting the notion that MCV causes a subset of MCC.
Journal ArticleDOI
Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary Neuroendocrine Carcinomas
Klaus J. Busam,Achim A. Jungbluth,Natasha Rekthman,Daniel G. Coit,Melissa Pulitzer,Jason Bini,Reety Arora,Nicole Hanson,Jodie Tassello,Denise Frosina,Patrick S. Moore,Yuan Chang +11 more
TL;DR: It is found that neuroendocrine carcinomas of the skin arising in association with a squamous cell carcinoma seem to be independent of MCV, and CM2B4 is a useful reagent for the diagnosis of MCC.
Journal ArticleDOI
Survivin Is a Therapeutic Target in Merkel Cell Carcinoma
Reety Arora,Masahiro Shuda,Anna Guastafierro,Huichen Feng,Tuna Toptan,Yanis L. Tolstov,Daniel P. Normolle,Laura L. Vollmer,Andreas Vogt,Alexander Dömling,Jeffrey L. Brodsky,Yuan Chang,Patrick S. Moore +12 more
TL;DR: Genetic data can be applied to help identify the cause of a cancer and thus point the way to new targets that can be exploited therapeutically, as well as identifying the molecular pathway that is activated in MCC cells by this virus.
Journal ArticleDOI
MCV and Merkel cell carcinoma: a molecular success story
TL;DR: Both MCV large and small T proteins promote cancer cell survival and proliferation and large T targets pocket proteins regulating cell cycle transit while small T activates cap-dependent translation critical for cancer cell growth.
Journal ArticleDOI
Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
Jingwei Cheng,Donglim Esther Park,Christian Berrios,Elizabeth A. White,Reety Arora,Rosa Yoon,Timothy Branigan,Tengfei Xiao,Thomas Westerling,Thomas Westerling,Alexander J. Federation,Rhamy Zeid,Benjamin J. Strober,Selene K. Swanson,Laurence Florens,James E. Bradner,James E. Bradner,Myles Brown,Peter M. Howley,Megha Padi,Michael P. Washburn,Michael P. Washburn,James A. DeCaprio,James A. DeCaprio +23 more
TL;DR: It is demonstrated that ST can activate gene expression in a EP400 and MYCL dependent manner and this activity contributes to cellular transformation and generation of induced pluripotent stem cells.