H
Hyun Jin Kwun
Researcher at Pennsylvania State University
Publications - 43
Citations - 3108
Hyun Jin Kwun is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Merkel cell polyomavirus & Merkel cell carcinoma. The author has an hindex of 25, co-authored 40 publications receiving 2824 citations. Previous affiliations of Hyun Jin Kwun include Penn State Milton S. Hershey Medical Center & UPRRP College of Natural Sciences.
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Journal ArticleDOI
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
Masahiro Shuda,Huichen Feng,Hyun Jin Kwun,Steven T. Rosen,Ole Gjoerup,Patrick S. Moore,Yuan Chang,Yuan Chang +7 more
TL;DR: It is shown that tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by LT but do eliminate viral DNA replication capacity, suggesting that MCV-positive MCC tumor cells undergo selection for LT mutations to prevent autoactivation of integrated virus replication that would be detrimental to cell survival.
Journal ArticleDOI
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.
Masahiro Shuda,Reety Arora,Hyun Jin Kwun,Huichen Feng,Ronit Sarid,María Teresa Fernández-Figueras,Yanis L. Tolstov,Ole Gjoerup,Mahesh Mansukhani,Steven H. Swerdlow,Preet M. Chaudhary,John M. Kirkwood,Michael A. Nalesnik,Jeffrey A. Kant,Lawrence M. Weiss,Patrick S. Moore,Yuan Chang +16 more
TL;DR: A monoclonal antibody is developed that specifically recognizes endogenous and transfected MCV large T (LT) antigen and expression of this putative viral oncoprotein in tumor cells provides the mechanistic underpinning supporting the notion that MCV causes a subset of MCC.
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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
TL;DR: It is shown that MCV small T (sT) antigen is expressed in most MCC tumors, where it is required for tumor cell growth and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers.
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Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1
TL;DR: It is reported that HBV X protein (HBx) represses E-cadherin expression at the transcription level by inducing methylation-mediated promoter inactivation and suggests that HBx plays a role during hepatocellular carcinogenesis by favoring cell detachment from the surrounding cells and migration outside of the primary tumor site.
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Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7
TL;DR: SCF(Fbw7) knockdown mimics sT-mediated stabilization of LT, but this knockdown is insufficient to fully reconstitute the transforming activity of a mutant LSD sT protein.