H
Huichen Feng
Researcher at University of Pittsburgh
Publications - 38
Citations - 6547
Huichen Feng is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Merkel cell polyomavirus & Cell culture. The author has an hindex of 26, co-authored 35 publications receiving 6083 citations. Previous affiliations of Huichen Feng include University of Hong Kong.
Papers
More filters
Journal ArticleDOI
Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
Yanis L. Tolstov,Diana V. Pastrana,Huichen Feng,J. C. Becker,Frank J. Jenkins,Stergios J. Moschos,Yuan Chang,Christopher B. Buck,Patrick S. Moore +8 more
TL;DR: It is demonstrated that Merkel cell polyomavirus is a widespread but previously unrecognized human infection and MCC patients have a markedly elevated MCV IgG response compared with control patients.
Journal ArticleDOI
Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
Sai Wah Tsao,Xianghong Wang,Yu Liu,Yuk Chun Cheung,Huichen Feng,Zhong Zheng,Natalie Wong,Po Wing Yuen,Angela K. F. Lo,Y.C. Wong,Dolly P. Huang +10 more
TL;DR: Two immortalized NP cell lines are established using SV40T and HPV16E6/E7 oncogenes and showed that these two cell lines contained multiple genetic alterations, some of which have been described in NPC, which provide a possible cell model system for studying the mechanisms involved in the tumorigenesis of NPC.
Journal Article
Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells.
Xianghong Wang,Dong-Yan Jin,Raymond W. M. Ng,Huichen Feng,Yong C Wong,Annie L.M. Cheung,S.W. Tsao +6 more
TL;DR: It is suggested that the steady-state amount of MAD2 inside cells may represent a molecular switch for mitotic checkpoint control and provide a novel insight into the molecular basis of CIN in ovarian carcinoma and has implications for effective use of checkpoint-targeting drugs.
Journal ArticleDOI
Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7
TL;DR: SCF(Fbw7) knockdown mimics sT-mediated stabilization of LT, but this knockdown is insufficient to fully reconstitute the transforming activity of a mutant LSD sT protein.
Journal ArticleDOI
Survivin Is a Therapeutic Target in Merkel Cell Carcinoma
Reety Arora,Masahiro Shuda,Anna Guastafierro,Huichen Feng,Tuna Toptan,Yanis L. Tolstov,Daniel P. Normolle,Laura L. Vollmer,Andreas Vogt,Alexander Dömling,Jeffrey L. Brodsky,Yuan Chang,Patrick S. Moore +12 more
TL;DR: Genetic data can be applied to help identify the cause of a cancer and thus point the way to new targets that can be exploited therapeutically, as well as identifying the molecular pathway that is activated in MCC cells by this virus.