H
Huige Li
Researcher at University of Mainz
Publications - 172
Citations - 15521
Huige Li is an academic researcher from University of Mainz. The author has contributed to research in topics: Enos & Oxidative stress. The author has an hindex of 60, co-authored 157 publications receiving 13033 citations. Previous affiliations of Huige Li include Central South University.
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Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene.
TL;DR: This article showed that dexamethasone increased mean arterial blood pressure in wild-type C-57 Bl6 mice (eNOS+/+ mice), but had no effect on blood pressure of mice with a disrupted eNOS gene (e-NOS-/- mice) derived from the same strain.
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Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells
Daniel Siuda,Ulrich Zechner,Nady El Hajj,Dirk Prawitt,David Langer,Ning Xia,Sven Horke,Andrea Pautz,Hartmut Kleinert,Ulrich Förstermann,Huige Li +10 more
TL;DR: HDAC inhibition decreases Nox4 transcription in human endothelial cells by preventing the binding of transcription factor and polymerase to the Nox 4 promoter, most likely because of a hyperacetylation-mediated steric inhibition.
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The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
Andy W C Man,Huige Li,Ning Xia +2 more
TL;DR: Recent findings are summarized, the molecular mechanisms and the potential of SIRT1 as a therapeutic target for the treatment of vascular diseases are reviewed, and future research directions are discussed.
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Ascorbic Acid Reduces Noise‐Induced Nitric Oxide Production in the Guinea Pig Ear
Ulf-Rüdiger Heinrich,Ilka Fischer,Jürgen Brieger,Andreas Rümelin,Irene Schmidtmann,Huige Li,Wolf J. Mann,Kai Helling +7 more
TL;DR: To identify the effect of ascorbic acid on tissue‐dependent NO content in the inner ear of the guinea pig, the local NO production in the organ of Corti and the lateral wall separately 6 hours after noise exposure was determined.
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Cyclooxygenase 2-Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs Induce Oxidative Stress by Up-Regulating Vascular NADPH Oxidases
Huige Li,Marcus Hortmann,Andreas Daiber,Matthias Oelze,Mir Abolfazl Ostad,Petra Schwarz,Hui Xu,Ning Xia,Andrei L. Kleschyov,Christian F. Mang,Ascan Warnholtz,Thomas Münzel,Ulrich Förstermann +12 more
TL;DR: The results indicate that NSAIDs may increase cardiovascular risk by inducing oxidative stress in the vasculature, with nonselective NSAIDs being even more critical than coxibs in this respect.