H
Huige Li
Researcher at University of Mainz
Publications - 172
Citations - 15521
Huige Li is an academic researcher from University of Mainz. The author has contributed to research in topics: Enos & Oxidative stress. The author has an hindex of 60, co-authored 157 publications receiving 13033 citations. Previous affiliations of Huige Li include Central South University.
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Journal ArticleDOI
Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and Angiogenesis
Lothar Rössig,Huige Li,Beate Fisslthaler,Carmen Urbich,Ingrid Fleming,Ulrich Förstermann,Andreas M. Zeiher,Stefanie Dimmeler +7 more
TL;DR: Exogenous NO reversed the inhibition of angiogenesis by TSA and indicated that HDAC-dependent mechanisms contribute to the regulation of eNOS expression in ECs.
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Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models
Swenja Kröller-Schön,Sebastian Steven,Sabine Kossmann,Alexander Scholz,Steffen Daub,Matthias Oelze,Ning Xia,Michael Hausding,Yuliya Mikhed,Elena Zinssius,Michael Mader,Paul Stamm,Nicolai Treiber,Karin Scharffetter-Kochanek,Huige Li,Eberhard Schulz,Philip Wenzel,Thomas Münzel,Andreas Daiber +18 more
TL;DR: The data show that mtROS trigger the activation of phagocytic and cardiovascular NADPH oxidases, which may have fundamental implications for immune cell activation and development of AT-II-induced hypertension.
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The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.
Sebastian Steven,Matthias Oelze,Alina Hanf,Swenja Kröller-Schön,Fatemeh Kashani,Siyer Roohani,Philipp Welschof,Maximilian Kopp,Ute Gödtel-Armbrust,Ning Xia,Huige Li,Eberhard Schulz,Karl J. Lackner,Leszek Wojnowski,Serge P. Bottari,Philip Wenzel,Eric Mayoux,Thomas Münzel,Andreas Daiber,Andreas Daiber +19 more
TL;DR: Empagliflozin reduces glucotoxicity and thereby prevents the development of endothelial dysfunction, reduces oxidative stress and exhibits anti-inflammatory effects in ZDF rats, despite persisting hyperlipidemia and hyperinsulinemia.
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Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II–Treated Rats
Matthias Oelze,Andreas Daiber,Ralf P. Brandes,Marcus Hortmann,Philip Wenzel,Ulrich Hink,Eberhard Schulz,Hanke Mollnau,Alexandra von Sandersleben,Andrei L. Kleschyov,Alexander Mülsch,Huige Li,Ulrich Förstermann,Thomas Münzel +13 more
TL;DR: Findings indicate that nebivolol interferes with the assembly of NADPH oxidase, which may explain, at least in part, its beneficial effect on endothelial function in angiotensin II–induced hypertension.
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A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase
TL;DR: The increase in eNOS in response to red wine involves several polyphenolic compounds with a major contribution from trans-resveratrol and lesser contributions from cinnamic and hydroxycinnamic acids, cyanidin, and some phenolic acids.