H
Huiping Zhang
Researcher at Centre for Life
Publications - 20
Citations - 474
Huiping Zhang is an academic researcher from Centre for Life. The author has contributed to research in topics: Mycolic acid & Tsukamurella pulmonis. The author has an hindex of 8, co-authored 19 publications receiving 356 citations.
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Journal ArticleDOI
Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of its Biosynthesis.
Yudai Matsuda,Takaaki Mitsuhashi,Shoukou Lee,Manabu Hoshino,Takahiro Mori,Masahiro Okada,Huiping Zhang,Fumiaki Hayashi,Makoto Fujita,Ikuro Abe +9 more
TL;DR: Genome mining of a terpene synthase gene from Emericella variecolor NBRC 32302 and its functional expression in Aspergillus oryzae led to the production of the new sesterterpene hydrocarbon, astellifadiene, having a 6-8-6-5-fused ring system.
Journal ArticleDOI
Genome-Based Discovery of an Unprecedented Cyclization Mode in Fungal Sesterterpenoid Biosynthesis.
Masahiro Okada,Yudai Matsuda,Takaaki Mitsuhashi,Shotaro Hoshino,Takahiro Mori,Kazuya Nakagawa,Zhiyang Quan,Bin Qin,Huiping Zhang,Fumiaki Hayashi,Hiroshi Kawaide,Ikuro Abe +11 more
TL;DR: A mechanistic study of the unusual fungal sesterterpene synthase EvQS indicated that the biosynthesis employs an unprecedented cyclization mode, which involves three rounds of hydride shifts and two successive C-C bond migrations to construct the 5-6-5-5 fused ring system of 1.
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Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum
Yudai Matsuda,Taiki Iwabuchi,Takayuki Fujimoto,Takayoshi Awakawa,Yu Nakashima,Takahiro Mori,Huiping Zhang,Fumiaki Hayashi,Ikuro Abe +8 more
TL;DR: The biosynthetic gene cluster of 1 (the prh cluster) is identified and the pathway up to berkeleydione (2) is elucidated, which serves as the key intermediate for the biosynthesis of 1 as well as many other meroterpenoids.
Journal ArticleDOI
Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium.
Shotaro Hoshino,Masahiro Okada,Toshiyuki Wakimoto,Huiping Zhang,Fumiaki Hayashi,Hiroyasu Onaka,Ikuro Abe +6 more
TL;DR: A terrestrial bacterium, Streptomyces sp.
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The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi.
TL;DR: Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A.