Hyeyoung Nam

TL;DR: Collectively, these data provide significant insight into the biology of aggressive RCC and demonstrate a novel role for DNA methylation in the promotion of HIF signaling and invasive phenotypes in renal cancer.

TL;DR: The transcription factor PRDM16 is epigenetically silenced in kidney cancer and loss of this factor’s repressive properties promotes HIF-mediated induction of the protumorigenic factor SEMA5B, which provides a novel epigenetic mechanism by which HIF signaling is promoted in this malignancy.

TL;DR: A novel role for PGC1α in the regulation of proinvasive SNAIL proteins is demonstrated and this work reports that the decreased expression of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha and the increased expression of several genes encoding collagen family members are associated with RCC tumor progression.

TL;DR: It is observed that AMP-activated protein kinase–mediated phosphorylation at Ser-99 promotes TET2 stability and increases global DNA 5-hydroxymethylcytosine levels and that protein phosphatase 2A can interact with Tet2 and dephosphorylate Ser- 99.

TL;DR: A novel role for L-2-hydroxyglutarate dehydrogenase in the kidney is demonstrated as well as new insight into the mechanisms that regulate expression of this enzyme.