H
Hyung-Jun Kim
Researcher at Seoul National University
Publications - 100
Citations - 4704
Hyung-Jun Kim is an academic researcher from Seoul National University. The author has contributed to research in topics: Engineering & Chemistry. The author has an hindex of 21, co-authored 76 publications receiving 3822 citations. Previous affiliations of Hyung-Jun Kim include UPRRP College of Natural Sciences & Howard Hughes Medical Institute.
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Journal ArticleDOI
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
Andrew Elden,Hyung-Jun Kim,Michael P. Hart,Alice Chen-Plotkin,Brian S. Johnson,Xiaodong Fang,Maria Armakola,Felix Geser,Robert W. Greene,Min Min Lu,Arun Padmanabhan,Dana Clay-Falcone,Leo McCluskey,Lauren Elman,Denise Juhr,Peter J. Gruber,Udo Rüb,Georg Auburger,John Q. Trojanowski,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,Nancy M. Bonini,Aaron D. Gitler +22 more
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.
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Conductivity enhancement in single-walled carbon nanotube bundles doped with K and Br
TL;DR: In this article, the authors report the doping of bulk samples of carbon nanotubes by vapour-phase reactions with bromine and potassium, a prototypical electron acceptor and donor respectively.
Journal ArticleDOI
Depression and Internet Addiction in Adolescents
Jee Hyun Ha,Suyeon Kim,Soojeong C. Bae,Sujin Bae,Hyung-Jun Kim,Minyoung Sim,In Kyoon Lyoo,Soo Churl Cho +7 more
TL;DR: A significant association between Internet addiction and depressive symptoms in adolescents is revealed and the data suggest the necessity of the evaluation of the potential underlying depression in the treatment of Internet-addicted adolescents.
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A yeast functional screen predicts new candidate ALS disease genes
Julien Couthouis,Michael P. Hart,James Shorter,Mariely DeJesus-Hernandez,Renske Erion,Rachel Oristano,Annie X. Liu,Daniel M. Ramos,Niti Jethava,Divya Hosangadi,James Epstein,Ashley Chiang,Zamia Diaz,Tadashi Nakaya,Fadia Ibrahim,Hyung-Jun Kim,Jennifer A. Solski,Kelly L. Williams,Jelena Mojsilovic-Petrovic,Caroline Ingre,Kevin B. Boylan,Neill R. Graff-Radford,Dennis W. Dickson,Dana Clay-Falcone,Lauren Elman,Leo McCluskey,Robert W. Greene,Robert G. Kalb,Virginia M.-Y. Lee,John Q. Trojanowski,Albert C. Ludolph,Wim Robberecht,Peter M. Andersen,Garth A. Nicholson,Ian P. Blair,Oliver D. King,Nancy M. Bonini,Vivianna M. Van Deerlin,Rosa Rademakers,Zissimos Mourelatos,Aaron D. Gitler +40 more
TL;DR: It is proposed that aggregation-prone RNA-binding proteins might contribute very broadly to ALS pathogenesis and the genes identified in the yeast functional screen, coupled with prion-like domain prediction analysis, now provide a powerful resource to facilitate ALS disease gene discovery.
Journal ArticleDOI
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
Hyung-Jun Kim,Alya R. Raphael,Eva S. LaDow,Leeanne McGurk,Ross A Weber,John Q. Trojanowski,Virginia M.-Y. Lee,Steven Finkbeiner,Aaron D. Gitler,Nancy M. Bonini +9 more
TL;DR: The efficacy of a small molecule inhibitor of eIF2α phosphorylation in ALS models was investigated and it was found that treatment with this inhibitor mitigated TDP-43 toxicity in flies and mammalian neurons.