H
Hywel David Williams
Researcher at Monash University
Publications - 45
Citations - 3410
Hywel David Williams is an academic researcher from Monash University. The author has contributed to research in topics: Solubility & Bioavailability. The author has an hindex of 24, co-authored 44 publications receiving 2851 citations. Previous affiliations of Hywel David Williams include Capsugel & Monash University, Parkville campus.
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
50 years of oral lipid-based formulations: Provenance, progress and future perspectives ☆
Orlagh M. Feeney,Matthew F. Crum,Claire Louise McEvoy,Natalie L. Trevaskis,Hywel David Williams,Colin W. Pouton,William N. Charman,Christel A. S. Bergström,Christopher J.H. Porter +8 more
TL;DR: A review of lipid-based formulations can be found in this paper, where the authors provide a brief retrospective assessment of the development of LBF over the past fifty years and provide a detailed analysis of the ability of LBFs to promote intestinal solubilisation, supersaturation and absorption.
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Toward the establishment of standardized in vitro tests for lipid‐based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations
Hywel David Williams,Philip Jonas Sassene,Karen Kleberg,Jean-Claude Bakala-N'Goma,Marilyn Calderone,Vincent Jannin,Annabel Igonin,Anette Partheil,Delphine Marchaud,Eduardo Jule,Jan Vertommen,Mario Maio,Ross Blundell,Hassan Benameur,Frédéric Carrière,Anette Müllertz,Christopher J.H. Porter,Colin W. Pouton +17 more
TL;DR: In this article, baseline conditions for the conduct of digestion tests are suggested and a series of eight model LBFs are described to probe test performance across different formulation types. Digestion experiments were performed in vitro using a pHstat apparatus and danazol employed as a model poorly water-soluble drug.
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Lipid Digestion as a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems
Mette Uhre Anby,Hywel David Williams,Michelle P. McIntosh,Hassan Benameur,Glenn A. Edwards,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The data suggest that digestion acts as a "trigger" for enhanced supersaturation and that solubilization/precipitation behavior is correlated with the degree of supersaturation on dispersion (S(M)DISP) or digestion (S (M)DIGEST).
Journal ArticleDOI
Transformation of Poorly Water-Soluble Drugs into Lipophilic Ionic Liquids Enhances Oral Drug Exposure from Lipid Based Formulations
Yasemin Sahbaz,Hywel David Williams,Tri-Hung Nguyen,Jessica Saunders,Leigh Ford,Susan A. Charman,Peter J. Scammells,Christopher J.H. Porter +7 more
TL;DR: The data suggest that the formation of lipophilic ionic liquids provides a means of increasing dissolved-drug loading in lipid based formulations and thereby promoting the exposure of poorly water-soluble drugs after oral administration.