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I. Gabrielle M. Brons
Researcher at University of Cambridge
Publications - 7
Citations - 2133
I. Gabrielle M. Brons is an academic researcher from University of Cambridge. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 6, co-authored 7 publications receiving 2005 citations.
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Journal ArticleDOI
Derivation of pluripotent epiblast stem cells from mammalian embryos
I. Gabrielle M. Brons,Lucy E. Smithers,Matthew Trotter,Peter J. Rugg-Gunn,Bowen Sun,Susana M. Chuva de Sousa Lopes,Sarah K. Howlett,Amanda Clarkson,Lars Ährlund-Richter,Roger A. Pedersen,Ludovic Vallier +10 more
TL;DR: It is shown that pluripotent stem cells can be derived from the late epiblast layer of post-implantation mouse and rat embryos using chemically defined, activin-containing culture medium that is sufficient for long-term maintenance of human embryonic stem cells.
Journal ArticleDOI
An overview on the development of a bio-artificial pancreas as a treatment of insulin-dependent diabetes mellitus.
TL;DR: This paper presents the concept and most of the research undertaken all over the world for the development of a bio‐artificial pancreas (BAP) device over the last 30 years.
Journal ArticleDOI
Status of genomic imprinting in epigenetically distinct pluripotent stem cells.
Bowen Sun,Mitsuteru Ito,Sasha Mendjan,Yoko Ito,I. Gabrielle M. Brons,Adele Murrell,Ludovic Vallier,Anne C. Ferguson-Smith,Roger A. Pedersen +8 more
TL;DR: It is found that mouse induced pluripotent stem cells (iPSCs) tend to lose imprinting similar to mouse ESCs, confirming the view that hESCs and EpiSCs are in vitro counterparts, sharing an epigenetic status distinct from ESCs and iPSCs.
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Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts.
Julien Maruotti,Xiang Peng Dai,Vincent Brochard,Luc Jouneau,Jun Liu,Amélie Bonnet-Garnier,Hélène Jammes,Ludovic Vallier,I. Gabrielle M. Brons,Roger A. Pedersen,Jean-Paul Renard,Jean-Paul Renard,Qi Zhou,Alice Jouneau,Alice Jouneau +14 more
TL;DR: EpiSCs derived from NT embryos appear to be incorrectly reprogrammed, indicating that abnormal epigenetic marks are imposed on cells in NT embryos during the transition from early to late epiblast.
Journal ArticleDOI
An Overview on the Development of a Bio‐Artificial Pancreas as a Treatment of Insulin‐Dependent Diabetes Mellitus
TL;DR: The concept and most of the research undertaken all over the world for the development of a bio-artificial pancreas (BAP) device over the last 30 years is described in this paper.