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Ian Chopra
Researcher at University of Leeds
Publications - 159
Citations - 13589
Ian Chopra is an academic researcher from University of Leeds. The author has contributed to research in topics: Antibacterial agent & Escherichia coli. The author has an hindex of 56, co-authored 159 publications receiving 12349 citations. Previous affiliations of Ian Chopra include University of Ljubljana & British Society for Antimicrobial Chemotherapy.
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Antibacterial Agents: Basis of Action
Ian Chopra,David Greenwood +1 more
TL;DR: Antibacterial agents alleviate infection through a variety of modes of action including the inhibition of protein, nucleic acid and cell wall synthesis.
Journal ArticleDOI
Regulatory opportunities to encourage technology solutions to antibacterial drug resistance
Roger Finch,Martin J. Blaser,Otto Carrs,Gail Cassell,Neil Fishman,Robert Guidos,Stuart Levy,John H. Powers,Ragnar Norrby,Glenn Tillotson,Rick Davies,Steven J. Projan,Michael J. Dawson,Dominique Monnet,Marcus Keogh-Brown,Kieran Hand,Sarah Garner,David Findlay,Chantal M. Morel,Richard Wise,Richard Bax,Frances Burke,Ian Chopra,Lloyd Czaplewski,David M. Livermore,Laura J. V. Piddock,Tony White +26 more
TL;DR: The 'Urgent Need' Working Party to address the regeneration of antibacterial drug discovery and development identified a number of issues, including increased application of pharmacokinetic/pharmacodynamic principles to expedite drug development; the need to prioritize licensing of drugs active in life-threatening infections; and expansion of the use of surrogate markers and rapid point of care diagnostics to facilitate drug development.
Journal ArticleDOI
SB 205952, a novel semisynthetic monic acid analog with at least two modes of action.
TL;DR: The biological properties of SB 205952, a nitrofuryl oxazole derivative of monic acid, differ from those of the closely related antibacterial agent mupirocin, and it is proposed that it possesses one or more mechanisms of action in addition to IRS inhibition, probably mediated by its nitrol component.
Journal ArticleDOI
6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase.
Veronika Škedelj,Emilija Arsovska,Tihomir Tomašič,Ana Kroflič,Vesna Hodnik,Martina Hrast,Marija Bešter-Rogač,Gregor Anderluh,Stanislav Gobec,Julieanne M. Bostock,Ian Chopra,Alex J. O'Neill,Christopher P. Randall,Anamarija Zega +13 more
TL;DR: New ATP-competitive inhibitors of DdlB are discovered, which may serve as a starting point for development of more potent inhibitors ofDdlB that could include both, an ATP- competitive and D-Ala competitive moiety.