Ian Chopra

TL;DR: The murF gene from Chlamydia trachomatis was shown to be capable of complementing a conditional Escherichia coli mutant impaired in UDP-MurNAc-tripeptide:d-Ala-d- ala ligase activity, which is expected for the chlamydial pentapeptide stem.

TL;DR: The molecular design program SPROUT has been used in conjunction with the X-ray cocrystal structure of Thermus thermophilus RNAP with MyxB to design novel inhibitors based on a substituted pyridyl-benzamide scaffold, which inhibited Escherichia coli RNAP.

TL;DR: The changes in the susceptibility of PBP 2a, 2b and 3 mutants to beta-lactam antibiotics imply that these PBPs are killing targets, consistent with the fact that thesePBPs are also important for shape determination and peptidoglycan synthesis.

TL;DR: Application of structure-based virtual screening to the National Cancer Institute library and the structure of the glycosyltransferase domain of the Staphylococcus aureus penicillin-binding protein 2 resulted in the identification of two small molecules analogues that exhibit antibacterial activity against several Gram-positive bacteria but were less active on Gram-negative bacteria.

TL;DR: Ellipticines and 9-acridinylamines were both found to possess inhibitory activity against Ddl from Escherichia coli and antimicrobial activity against E. coli and Staphylococcus aureus.