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Ian Chopra
Researcher at University of Leeds
Publications - 159
Citations - 13589
Ian Chopra is an academic researcher from University of Leeds. The author has contributed to research in topics: Antibacterial agent & Escherichia coli. The author has an hindex of 56, co-authored 159 publications receiving 12349 citations. Previous affiliations of Ian Chopra include University of Ljubljana & British Society for Antimicrobial Chemotherapy.
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Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance
TL;DR: Growth as a biofilm facilitates the emergence of antibiotic resistance by mutation in Staphylococcus aureus and it is demonstrated that biofilm growth of this species also dramatically increases horizontal transfer of plasmid-borne antibiotic resistance determinants by conjugation/mobilization.
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The role of mutators in the emergence of antibiotic-resistant bacteria.
TL;DR: Mutators are a risk factor during the treatment of bacterial infections as they appear to enhance the selection of mutants expressing high- and low-level antibiotic resistance and have the capacity to refine existing plasmid-located resistance determinants.
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Short‐chain organic acids at pH 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation
TL;DR: Cell death was not associated with a reduction in culture turbidity or a loss of membrane integrity since morphologically normal membranes were observed by electron microscopy and only a small proportion of the cytoplasmic enzyme beta-galactosidase leaked into the supernatant fluid of acid-treated E. coli K12 cultures.
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Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
Ian Chopra,Christopher J. Schofield,Martin J. Everett,Alex J. O'Neill,Keith W. Miller,Mark H. Wilcox,Jean-Marie Frère,Michael J. Dawson,Lloyd George Czaplewski,Uros Urleb,Patrice Courvalin +10 more
TL;DR: This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the issues associated with the treatment of hospital infections caused by Gram-negative bacteria.
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Increased mutability of Pseudomonas aeruginosa in biofilms
TL;DR: Down-regulation of antioxidant enzymes in P. aeruginosa biofilms may enhance the rate of mutagenic events due to the accumulation of DNA damage and provide a further source of antibiotic-resistant mutants in the CF lung.