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Ian Chopra
Researcher at University of Leeds
Publications - 159
Citations - 13589
Ian Chopra is an academic researcher from University of Leeds. The author has contributed to research in topics: Antibacterial agent & Escherichia coli. The author has an hindex of 56, co-authored 159 publications receiving 12349 citations. Previous affiliations of Ian Chopra include University of Ljubljana & British Society for Antimicrobial Chemotherapy.
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A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates
TL;DR: It is shown that fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa strains reported in Scandinavia form part of a European epidemic clonotype that carries the fusB determinant.
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Towards new business models for R&D for novel antibiotics.
Anthony D. So,Neha Gupta,Samir K. Brahmachari,Ian Chopra,Bernard H. Munos,Carl Nathan,Kevin Outterson,J.P. Paccaud,D.J. Payne,Rosanna W. Peeling,M. Spigelman,J. Weigelt +11 more
TL;DR: To effect changes in the face of a growing global burden of resistance to existing antibiotics, both public and private sector stakeholders must show greater commitment to an R&D agenda that will address this problem, not only for industrialized countries but also globally.
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XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
TL;DR: XF-73 exhibited rapid membrane-perturbing activity, which is likely to be responsible for inhibition of macromolecular synthesis and the death of staphylococci exposed to the drug.
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Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.
TL;DR: The responses of hypermutable Escherichia coli strains to selection with antibiotics having different endogenous resistance potentials were determined and emphasize that successful new drugs will need to possess low endogenous resistance Potential.
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The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century
TL;DR: Some of the technical reasons for the recent failure in antibacterial drug discovery are considered and the future developments that may help to reverse the poor current success rate are looked to.