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Ian R. Humphreys
Researcher at Cardiff University
Publications - 88
Citations - 2909
Ian R. Humphreys is an academic researcher from Cardiff University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 27, co-authored 75 publications receiving 2392 citations. Previous affiliations of Ian R. Humphreys include La Jolla Institute for Allergy and Immunology & Imperial College London.
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Journal ArticleDOI
Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation
Ceri Alan Fielding,Gareth W. Jones,Rachel M. McLoughlin,Louise McLeod,Victoria Jayne Hammond,Javier Uceda,Anwen Sian Williams,Mark Lambie,Thomas L. Foster,Chia-Te Liao,Christopher M. Rice,Claire J. Greenhill,Chantal Sophie Colmont,Emily Hams,Barbara Coles,Ann Kift-Morgan,Zarabeth Newton,Katherine J. Craig,John D. Williams,Geraint T. Williams,Simon J. Davies,Ian R. Humphreys,Valerie B. O'Donnell,Philip R. Taylor,Brendan J. Jenkins,Nicholas Topley,Simon Arnett Jones +26 more
TL;DR: Fibrosis is observed in mice lacking interferon-γ (IFN-γ), STAT1, or RAG-1 and IL-6 causes compromised tissue repair by shifting acute inflammation into a more chronic profibrotic state through induction of Th1 cell responses as a consequence of recurrent inflammation.
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Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.
Timothy C. Cheung,Ian R. Humphreys,Karen G. Potter,Paula S. Norris,Heather M. Shumway,Bonnie R. Tran,Ginelle Patterson,Rochelle Jean-Jacques,Miri Yoon,Patricia G. Spear,Kenneth M. Murphy,Nell S. Lurain,Chris A. Benedict,Carl F. Ware +13 more
TL;DR: The demonstration that distinct herpesviruses target the HVEM-BTLA cosignaling pathway suggests the importance of this pathway in regulating T cell activation during host defenses.
Journal ArticleDOI
Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
TL;DR: The results indicate that modulating effector T cell differentiation can counteract pathogen exploitation of the mucosa, thus limiting persistent virus replication and transmission.
Journal ArticleDOI
A role for dendritic cells in the dissemination of mycobacterial infection
Ian R. Humphreys,Graham R. Stewart,David J. Turner,Janisha Patel,Danai Karamanou,Robert J. Snelgrove,Douglas B. Young +6 more
TL;DR: The results are consistent with a model in which mycobacterial dissemination from the lung is initiated by the migration of infected dendritic cells to the draining lymph nodes.
Journal ArticleDOI
Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection.
Valerie B. O'Donnell,David Thomas,Richard J. Stanton,Jean-Yves Maillard,Robert C. Murphy,Simon Arnett Jones,Ian R. Humphreys,Michael J.O. Wakelam,Christopher Fegan,Matt P. Wise,Albert Bosch,Syed A. Sattar +11 more
TL;DR: Reviewing known mechanisms of viral lipid membrane disruption by widely available dental mouthwash components that include ethanol, chlorhexidine, cetylpyridinium chloride, hydrogen peroxide, and povidone-iodine concludes that several deserve clinical evaluation.