I
Ian Said Huntingford
Researcher at Institute of Cancer Research
Publications - 3
Citations - 1297
Ian Said Huntingford is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Somatic evolution in cancer & Cancer. The author has an hindex of 3, co-authored 3 publications receiving 824 citations. Previous affiliations of Ian Said Huntingford include Mater Dei Hospital.
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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis,Somaieh Hedayat,Alexandra Vatsiou,Yann Jamin,Javier Fernández-Mateos,Khurum Khan,Khurum Khan,Andrea Lampis,Katherine Eason,Ian Said Huntingford,Rosemary Burke,Mihaela Rata,Dow-Mu Koh,Dow-Mu Koh,Nina Tunariu,Nina Tunariu,David J. Collins,Sanna Hulkki-Wilson,Chanthirika Ragulan,Inmaculada Spiteri,Sing Yu Moorcraft,Ian Chau,Sheela Rao,David Watkins,Nicos Fotiadis,Maria Antonietta Bali,Maria Antonietta Bali,Mahnaz Darvish-Damavandi,Hazel Lote,Hazel Lote,Zakaria Eltahir,Elizabeth C Smyth,Ruwaida Begum,Paul A. Clarke,Jens C. Hahne,Mitchell Dowsett,Johann S. de Bono,Paul Workman,Anguraj Sadanandam,Matteo Fassan,Owen J. Sansom,Suzanne A. Eccles,Naureen Starling,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Simon P. Robinson,David Cunningham,Nicola Valeri,Nicola Valeri +49 more
TL;DR: Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials are compared to suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
Journal ArticleDOI
Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.
Khurum Khan,Khurum Khan,David Cunningham,Benjamin Werner,Georgios Vlachogiannis,Inmaculada Spiteri,Timon Heide,Javier Fernandez Mateos,Alexandra Vatsiou,Andrea Lampis,Mahnaz Darvish Damavandi,Hazel Lote,Ian Said Huntingford,Somaieh Hedayat,Ian Chau,Nina Tunariu,Giulia Mentrasti,Francesco Trevisani,Sheela Rao,Gayathri Anandappa,Gayathri Anandappa,David Watkins,Naureen Starling,Janet Thomas,Clare Peckitt,Nasir Khan,Massimo Rugge,Ruwaida Begum,Blanka Hezelova,Annette Bryant,Thomas Jones,Paula Proszek,Matteo Fassan,Jens C. Hahne,Mike Hubank,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Nicola Valeri,Nicola Valeri +39 more
TL;DR: This study demonstrates how integrating frequently sampled longitudinal liquid biopsies with a mathematical framework of tumor evolution allows individualized quantitative forecasting of progression, providing novel opportunities for adaptive personalized therapies.
Journal ArticleDOI
The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer.
Peter A. Barry,Alexandra Vatsiou,Inmaculada Spiteri,Daniel Nichol,George D. Cresswell,Ahmet Acar,Nicholas A. Trahearn,Sarah Hrebien,Isaac Garcia-Murillas,Kate Chkhaidze,Luca Ermini,Ian Said Huntingford,Hannah Cottom,Lila Zabaglo,Konrad Koelble,Saira Khalique,Jennifer Rusby,Francesca Muscarà,Mitch Dowsett,Carlo C. Maley,Carlo C. Maley,Rachael Natrajan,Yinyin Yuan,Gaia Schiavon,Nicholas C. Turner,Andrea Sottoriva +25 more
TL;DR: This study sheds new light on a crucial evolutionary step in the natural history of breast cancer, demonstrating early establishment of axillary lymph node metastasis in a substantial proportion of patients.