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Nicos Fotiadis
Researcher at The Royal Marsden NHS Foundation Trust
Publications - 48
Citations - 2771
Nicos Fotiadis is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Medicine & Biopsy. The author has an hindex of 12, co-authored 36 publications receiving 1752 citations. Previous affiliations of Nicos Fotiadis include Government of the United Kingdom & Institute of Cancer Research.
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Journal ArticleDOI
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis,Somaieh Hedayat,Alexandra Vatsiou,Yann Jamin,Javier Fernández-Mateos,Khurum Khan,Khurum Khan,Andrea Lampis,Katherine Eason,Ian Said Huntingford,Rosemary Burke,Mihaela Rata,Dow-Mu Koh,Dow-Mu Koh,Nina Tunariu,Nina Tunariu,David J. Collins,Sanna Hulkki-Wilson,Chanthirika Ragulan,Inmaculada Spiteri,Sing Yu Moorcraft,Ian Chau,Sheela Rao,David Watkins,Nicos Fotiadis,Maria Antonietta Bali,Maria Antonietta Bali,Mahnaz Darvish-Damavandi,Hazel Lote,Hazel Lote,Zakaria Eltahir,Elizabeth C Smyth,Ruwaida Begum,Paul A. Clarke,Jens C. Hahne,Mitchell Dowsett,Johann S. de Bono,Paul Workman,Anguraj Sadanandam,Matteo Fassan,Owen J. Sansom,Suzanne A. Eccles,Naureen Starling,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Simon P. Robinson,David Cunningham,Nicola Valeri,Nicola Valeri +49 more
TL;DR: Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials are compared to suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
Journal ArticleDOI
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Stuart Horswell,Tim Chambers,Tim O'Brien,José I. López,Thomas B.K. Watkins,David Nicol,Mark Stares,Ben Challacombe,Steve Hazell,Ashish Chandra,Thomas J. Mitchell,Lewis Au,Claudia Eichler-Jonsson,Faiz Jabbar,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Aengus Stewart,Wei Xing,Jonathan C. Smith,Mickael Escudero,Adam Huffman,Nik Matthews,Greg Elgar,Ben Phillimore,Marta Costa,Sharmin Begum,Sophia Ward,Sophia Ward,Max Salm,Stefan Boeing,Rosalie Fisher,Lavinia Spain,Carolina Navas,Eva Grönroos,Sebastijan Hobor,Sarkhara Sharma,Ismaeel Aurangzeb,Sharanpreet Lall,Alexander Polson,Mary Varia,Catherine Horsfield,Nicos Fotiadis,Lisa Pickering,Roland F. Schwarz,Bruno Silva,Javier Herrero,Nicholas M. Luscombe,Mariam Jamal-Hanjani,Rachel Rosenthal,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Orsolya Pipek,Dezso Ribli,Marcin Krzystanek,István Csabai,Zoltan Szallasi,Zoltan Szallasi,Martin Gore,Nicholas McGranahan,Peter Van Loo,Peter Van Loo,Peter J. Campbell,James Larkin,Charles Swanton,Charles Swanton +76 more
TL;DR: The insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance and identify genetic diversity and chromosomal complexity as determinants of patient outcome.
Journal ArticleDOI
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
Thomas J. Mitchell,Samra Turajlic,Andrew Rowan,David Nicol,James H.R. Farmery,Tim O'Brien,Inigo Martincorena,Patrick S. Tarpey,Nicos Angelopoulos,Lucy R. Yates,Adam Butler,Keiran Raine,Grant D. Stewart,Ben Challacombe,Archana Fernando,José I. López,Steve Hazell,Ashish Chandra,Simon Chowdhury,Sarah Rudman,Aspasia Soultati,Gordon Stamp,Nicos Fotiadis,Lisa Pickering,Lewis Au,Lavinia Spain,Joanna Lynch,Mark Stares,Jon W. Teague,Francesco Maura,David C. Wedge,Stuart Horswell,Tim Chambers,Kevin Litchfield,Hang Xu,Aengus Stewart,Reza Elaidi,Stéphane Oudard,Nicholas McGranahan,István Csabai,Martin Gore,P. Andrew Futreal,James Larkin,Andy G. Lynch,Zoltan Szallasi,Charles Swanton,Peter J. Campbell +46 more
TL;DR: Analysis of whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma suggests that the number of cells with 3p loss capable of initiating sporadic tumors is no more than a few hundred.
Journal ArticleDOI
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas,Andrew Furness,Andrew Furness,Isabelle Solomon,Kroopa Joshi,Kroopa Joshi,Leila Mekkaoui,Marta H. Lesko,Enrique Miranda Rota,Rony Dahan,Andrew Georgiou,Anna Sledzinska,Assma Ben Aissa,Dafne Franz,Mariana Werner Sunderland,Yien Ning Sophia Wong,Jake Y. Henry,Tim O'Brien,David Nicol,Ben Challacombe,Stephen A. Beers,Samra Turajlic,Martin Gore,James Larkin,Charles Swanton,Kerry A. Chester,Martin Pule,Jeffrey V. Ravetch,Teresa Marafioti,Karl S. Peggs,Sergio A. Quezada,Lavinia Spain,Andrew Wotherspoon,Nicholas Francis,Myles Smith,Dirk C. Strauss,Andrew J. Hayes,Aspasia Soultati,Mark Stares,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Mariam Jamal-Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert E. Hynds,Gareth A. Wilson,Nicolai Juul Birkbak,Thomas B.K. Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Van Loo,Andrew Rowan,Hang Xu,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,John A. Hartley,Helen Lowe,Javier Herrero,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Natasha Iles,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jorda,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw +250 more
TL;DR: Use of an anti‐CD25 antibody with enhanced binding to activating Fc&ggr;Rs led to effective depletion of tumor‐infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.
Journal ArticleDOI
MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma
Andrea Lampis,Pietro Carotenuto,Georgios Vlachogiannis,Luciano Cascione,Somaieh Hedayat,Rosemary Burke,Paul A. Clarke,Else Bosma,Michele Simbolo,Aldo Scarpa,Sijia Yu,Rebecca Cole,Elizabeth C Smyth,Javier Fernandez Mateos,Ruwaida Begum,Blanka Hezelova,Zakaria Eltahir,Andrew Wotherspoon,Nicos Fotiadis,Maria Antonietta Bali,Chirag Nepal,Khurum Khan,Mark Stubbs,Jens C. Hahne,Pierluigi Gasparini,Vincenza Guzzardo,Carlo M. Croce,Suzanne A. Eccles,Matteo Fassan,Matteo Fassan,David Cunningham,Jesper B. Andersen,Paul Workman,Nicola Valeri,Nicola Valeri,Chiara Braconi,Chiara Braconi +36 more
TL;DR: In this article, the effects of HSP90 inhibitors on cells with disruption of the microRNA 21 (MIR21 or miRNA21) gene, cells incubated with MIR21 inhibitors, and stable cell lines with inducible expression of microRNA21 were investigated.