Z
Zakaria Eltahir
Researcher at The Royal Marsden NHS Foundation Trust
Publications - 21
Citations - 1949
Zakaria Eltahir is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Colorectal cancer & KRAS. The author has an hindex of 13, co-authored 19 publications receiving 1324 citations. Previous affiliations of Zakaria Eltahir include Institute of Cancer Research.
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Journal ArticleDOI
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis,Somaieh Hedayat,Alexandra Vatsiou,Yann Jamin,Javier Fernández-Mateos,Khurum Khan,Khurum Khan,Andrea Lampis,Katherine Eason,Ian Said Huntingford,Rosemary Burke,Mihaela Rata,Dow-Mu Koh,Dow-Mu Koh,Nina Tunariu,Nina Tunariu,David J. Collins,Sanna Hulkki-Wilson,Chanthirika Ragulan,Inmaculada Spiteri,Sing Yu Moorcraft,Ian Chau,Sheela Rao,David Watkins,Nicos Fotiadis,Maria Antonietta Bali,Maria Antonietta Bali,Mahnaz Darvish-Damavandi,Hazel Lote,Hazel Lote,Zakaria Eltahir,Elizabeth C Smyth,Ruwaida Begum,Paul A. Clarke,Jens C. Hahne,Mitchell Dowsett,Johann S. de Bono,Paul Workman,Anguraj Sadanandam,Matteo Fassan,Owen J. Sansom,Suzanne A. Eccles,Naureen Starling,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Simon P. Robinson,David Cunningham,Nicola Valeri,Nicola Valeri +49 more
TL;DR: Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials are compared to suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
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Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial
Elizabeth C Smyth,Andrew Wotherspoon,Clare Peckitt,David Gonzalez,Sanna Hulkki-Wilson,Zakaria Eltahir,Matteo Fassan,Massimo Rugge,Nicola Valeri,Nicola Valeri,Alicia Okines,Madeleine Hewish,William H. Allum,S. P. Stenning,Matthew Nankivell,Ruth E Langley,David Cunningham +16 more
TL;DR: In the MAGIC trial, MMRD and high MSI were associated with a positive prognostic effect in patients treated with surgery alone and a differentially negative prognosticEffect in patients treating with chemotherapy.
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MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma
Andrea Lampis,Pietro Carotenuto,Georgios Vlachogiannis,Luciano Cascione,Somaieh Hedayat,Rosemary Burke,Paul A. Clarke,Else Bosma,Michele Simbolo,Aldo Scarpa,Sijia Yu,Rebecca Cole,Elizabeth C Smyth,Javier Fernandez Mateos,Ruwaida Begum,Blanka Hezelova,Zakaria Eltahir,Andrew Wotherspoon,Nicos Fotiadis,Maria Antonietta Bali,Chirag Nepal,Khurum Khan,Mark Stubbs,Jens C. Hahne,Pierluigi Gasparini,Vincenza Guzzardo,Carlo M. Croce,Suzanne A. Eccles,Matteo Fassan,Matteo Fassan,David Cunningham,Jesper B. Andersen,Paul Workman,Nicola Valeri,Nicola Valeri,Chiara Braconi,Chiara Braconi +36 more
TL;DR: In this article, the effects of HSP90 inhibitors on cells with disruption of the microRNA 21 (MIR21 or miRNA21) gene, cells incubated with MIR21 inhibitors, and stable cell lines with inducible expression of microRNA21 were investigated.
Journal ArticleDOI
Effect of HER2 on prognosis and benefit from peri-operative chemotherapy in early oesophago-gastric adenocarcinoma in the MAGIC trial
Alicia Okines,L.C. Thompson,David Cunningham,A C Wotherspoon,Jorge S. Reis-Filho,Ruth E Langley,Tom Samuel Waddell,D. Noor,Zakaria Eltahir,Rachel Wong,Sally P. Stenning +10 more
TL;DR: Her2 status is not an independent prognostic biomarker in early oesophago-gastric adenocarcinoma and the power of the predictive analysis was limited by the small number of HER2 positive pre-treatment biopsies.
Journal ArticleDOI
KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.
Francesco Sclafani,Ian Chau,David Cunningham,Jens C. Hahne,George Vlachogiannis,Zakaria Eltahir,Andrea Lampis,Chiara Braconi,Chiara Braconi,Eleftheria Kalaitzaki,David Gonzalez de Castro,Andrew Wotherspoon,Jaume Capdevila,Bengt Glimelius,Noelia Tarazona,Ruwaida Begum,Hazel Lote,Hazel Lote,Sanna Hulkki Wilson,Giulia Mentrasti,Gina Brown,Diana Tait,Jacqueline Oates,Nicola Valeri,Nicola Valeri +24 more
TL;DR: While this study confirms the feasibility of ctDNA analysis in LARC and the high sensitivity of ddPCR, larger series are needed to better address the role of cTDNA as a prognostic or predictive tool in this setting.