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Ian W. Windsor
Researcher at Boston Children's Hospital
Publications - 21
Citations - 407
Ian W. Windsor is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Protease & Epitope. The author has an hindex of 7, co-authored 18 publications receiving 151 citations. Previous affiliations of Ian W. Windsor include Harvard University & Wisconsin Alumni Research Foundation.
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Journal ArticleDOI
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Pei Tong,Avneesh Gautam,Ian W. Windsor,Ian W. Windsor,Ian W. Windsor,Meghan Travers,Yuezhou Chen,Nicholas Garcia,Noah B. Whiteman,Lindsay G. A. McKay,Nadia Storm,Lauren E. Malsick,Anna N. Honko,Felipe J.N. Lelis,Shaghayegh Habibi,Simon Jenni,Yongfei Cai,Linda J. Rennick,W. Paul Duprex,Kevin R. McCarthy,Christy L. Lavine,Teng Zuo,Junrui Lin,Adam Zuiani,Jared Feldman,Elizabeth A. MacDonald,Blake M. Hauser,Anthony Griffths,Michael S. Seaman,Aaron G. Schmidt,Aaron G. Schmidt,Bing Chen,Donna Neuberg,Goran Bajic,Goran Bajic,Stephen C. Harrison,Duane R. Wesemann +36 more
TL;DR: The authors charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found seven major antibody competition groups against epitopes recurrently targeted across individuals.
Journal ArticleDOI
Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid.
Ian W. Windsor,Michael J. Palte,J.C. Lukesh rd.,Brian Gold,Katrina T. Forest,Ronald T. Raines +5 more
TL;DR: It is found that replacing an aniline moiety in darunavir with a phenylboronic acid leads to 20-fold greater affinity for the protease, which highlights the utility of boronic acids as versatile functional groups in the design of small-molecule ligands.
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Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease.
Elizabeth A. MacDonald,Gary Frey,Mark N. Namchuk,Stephen C. Harrison,Stephen C. Harrison,Stephen M. Hinshaw,Ian W. Windsor,Ian W. Windsor +7 more
TL;DR: The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ideal target for pharmaceutical inhibition as mentioned in this paper.
Journal ArticleDOI
Stereoelectronic Effects Impact Glycan Recognition
Caitlin M. McMahon,Christine R. Isabella,Ian W. Windsor,Paul Kosma,Ronald T. Raines,Laura L. Kiessling +5 more
TL;DR: The finding that hItln-1 avoids binding prevalent glycans with a terminal 1,2 diol suggests the lectin has evolved to recognize distinct bacterial species, and a role for stereoelectronic effects in dictating the specificity of glycan recognition by proteins is highlighted.
Journal ArticleDOI
Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity.
Ian W. Windsor,Ronald T. Raines +1 more
TL;DR: A fluorogenic substrate for HIV-1 protease was designed and used as the basis for a hypersensitive assay, which is capable of measuring Ki values as low as 0.25 pM, and well-suited for characterizing the next generation of HIV- 1 protease inhibitors.