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Ichiro Ito
Researcher at Gunma University
Publications - 59
Citations - 1555
Ichiro Ito is an academic researcher from Gunma University. The author has contributed to research in topics: Cancer & Carcinoma. The author has an hindex of 13, co-authored 54 publications receiving 1216 citations.
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Journal ArticleDOI
Mutational landscape and clonal architecture in grade II and III gliomas
Hiromichi Suzuki,Kosuke Aoki,Kenichi Chiba,Yusuke Sato,Yusuke Shiozawa,Yuichi Shiraishi,Teppei Shimamura,Atsushi Niida,Kazuya Motomura,Fumiharu Ohka,Takashi Yamamoto,Kuniaki Tanahashi,Melissa Ranjit,Toshihiko Wakabayashi,Tetsuichi Yoshizato,Keisuke Kataoka,Kenichi Yoshida,Yasunobu Nagata,Aiko Sato-Otsubo,Hiroko Tanaka,Masashi Sanada,Yutaka Kondo,Hideo Nakamura,Masahiro Mizoguchi,Tatsuya Abe,Yoshihiro Muragaki,Reiko Watanabe,Ichiro Ito,Satoru Miyano,Atsushi Natsume,Seishi Ogawa +30 more
TL;DR: In this article, the authors delineate the entire picture of genetic alterations and affected pathways in these glioma types, with sensitive detection of driver genes Grade II and III gliomas comprise three distinct subtypes characterized by discrete sets of mutations and distinct clinical behaviors, suggesting that there is functional interplay between the mutations that drive clonal selection.
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Prognostic relevance of genetic alterations in diffuse lower-grade gliomas.
Kosuke Aoki,Kosuke Aoki,Hideo Nakamura,Hiromichi Suzuki,Hiromichi Suzuki,Keitaro Matsuo,Keisuke Kataoka,Teppei Shimamura,Kazuya Motomura,Fumiharu Ohka,Satoshi Shiina,Takashi Yamamoto,Yasunobu Nagata,Tetsuichi Yoshizato,Tetsuichi Yoshizato,Masahiro Mizoguchi,Tatsuya Abe,Yasutomo Momii,Yoshihiro Muragaki,Reiko Watanabe,Ichiro Ito,Masashi Sanada,Hironori Yajima,Naoya Morita,Ichiro Takeuchi,Ichiro Takeuchi,Satoru Miyano,Toshihiko Wakabayashi,Seishi Ogawa,Atsushi Natsume +29 more
TL;DR: Subtype-specific genetic lesions can be used to stratify patients within each LGG subtype, enabling better prognostication and management.
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Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors.
Masahiro Endo,Kazuo Nakagawa,Yasuhisa Ohde,Takehiro Okumura,Haruhiko Kondo,Satoshi Igawa,Yukiko Nakamura,Asuka Tsuya,Haruyasu Murakami,Toshiaki Takahashi,Nobuyuki Yamamoto,Ichiro Ito,Toru Kameya +12 more
TL;DR: A significant relationship was seen between (18)F-FDG PET accumulation and histologic subtype in thymic epithelial tumors when they were classified into three groups.
Journal ArticleDOI
Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma.
Tadashi Ashizawa,Haruo Miyata,Akira Iizuka,Masaru Komiyama,Chie Oshita,Akiko Kume,Masahiro Nogami,Mika Yagoto,Ichiro Ito,Takuma Oishi,Reiko Watanabe,Koichi Mitsuya,Kenji Matsuno,Toshio Furuya,Tadashi Okawara,Masami Otsuka,Naohisa Ogo,Akira Asai,Yoko Nakasu,Ken Yamaguchi,Yasuto Akiyama +20 more
TL;DR: STX-0119, an inhibitor of STAT3, may serve as a novel therapeutic compound against GBM-SCs even in temozolomide-resistant GBM patients and has the potential for G BM-SC-specific therapeutics in combination with temozlomide plus radiation therapy.
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CAR T cells targeting podoplanin reduce orthotopic glioblastomas in mouse brains
Satoshi Shiina,Masasuke Ohno,Fumiharu Ohka,Shunichiro Kuramitsu,Akane Yamamichi,Akira Kato,Kazuya Motomura,Kuniaki Tanahashi,Takashi Yamamoto,Reiko Watanabe,Ichiro Ito,Takeshi Senga,Michinari Hamaguchi,Toshihiko Wakabayashi,Mika K. Kaneko,Yukinari Kato,Vidyalakshmi Chandramohan,Darell D. Bigner,Atsushi Natsume +18 more
TL;DR: T cells expressing a chimeric antigen receptor that targets podoplanin were specific and effective against PDPN-positive glioblastoma cells in vitro and increased survival time in a mouse model.