Atsushi Niida

TL;DR: This integrated molecular analysis of clear-cell renal cell carcinoma unmasked new correlations between DNA methylation, gene mutation and/or gene expression and copy number profiles, enabling the stratification of clinical risks for patients with ccRCC.

TL;DR: In this article, the authors delineate the entire picture of genetic alterations and affected pathways in these glioma types, with sensitive detection of driver genes Grade II and III gliomas comprise three distinct subtypes characterized by discrete sets of mutations and distinct clinical behaviors, suggesting that there is functional interplay between the mutations that drive clonal selection.

TL;DR: A novel TCF target gene, DKK1, is identified, which has been shown to be a potent inhibitor of Wnt signaling, and the finding suggests the existence of a novel feedback loop in Wnt signalling.

TL;DR: A large-scale genomic analysis of ESCCs from patients in Japan determined the mutational landscape of this cancer and associated environmental and genetic factors with base substitution patterns of somatic mutations and provide a registry of genes and pathways that are disrupted in ES CCs.

TL;DR: USAG-1 is shown to be a BMP antagonist that interacts with BMP-7 in the developing and adult kidney, and is suggested to be important in the development of kidney and preservation of adult renal functions under pathological stresses.