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Igor da S. Bomfim
Researcher at Federal University of Ceará
Publications - 5
Citations - 195
Igor da S. Bomfim is an academic researcher from Federal University of Ceará. The author has contributed to research in topics: Cytotoxicity & Biological activity. The author has an hindex of 4, co-authored 5 publications receiving 162 citations.
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Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl)quinoxalines, a promising and potent new class of anticancer agents
Felipe A. R. Rodrigues,Igor da S. Bomfim,Bruno C. Cavalcanti,Cláudia Pessoa,James L. Wardell,Solange M. S. V. Wardell,Alessandra C. Pinheiro,Carlos R. Kaiser,Thais C.M. Nogueira,John N. Low,Ligia R. Gomes,Marcus V. N. de Souza +11 more
TL;DR: The most active compound was (1: X,Y=2,3-(OH)2, Z=H), which displayed a potent cytotoxicity comparable to that of the reference drug doxorubicin.
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Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
Eduardo H. G. da Cruz,Molly A. Silvers,Guilherme A. M. Jardim,Jarbas M. Resende,Bruno C. Cavalcanti,Igor da S. Bomfim,Cláudia Pessoa,Carlos A. de Simone,Giancarlo V. Botteselle,Antonio L. Braga,Divya K. Nair,Irishi N. N. Namboothiri,David A. Boothman,Eufrânio N. da Silva Júnior +13 more
TL;DR: Selenium-containing quinone-based 1,2,3-triazoles were synthesized and evaluated against six types of cancer cell lines, and Mechanistic role for NAD(P)H Quinone Oxidoreductase 1 (NQO1) was explained.
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Mefloquine-oxazolidine derivatives: a new class of anticancer agents.
Felipe A. R. Rodrigues,Igor da S. Bomfim,Bruno C. Cavalcanti,Cláudia Pessoa,Raoni S.B. Goncalves,James L. Wardell,James L. Wardell,Solange M. S. V. Wardell,Marcus V. N. de Souza +8 more
TL;DR: The mefloquine–oxazolidine derivatives are considered to be useful leads for the rational design of new antitumor agents and molecular conformations do not play a significant role either.
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Synthesis and cytotoxic evaluation of a series of 2-amino-naphthoquinones against human cancer cells.
Thiago A. P. De Moraes,Maria José Sarmento Filha,Celso A. Camara,Tania M. S. Silva,Bruno Marques Soares,Igor da S. Bomfim,Cláudia Pessoa,George C. Ximenes,Valdemiro Amaro da Silva +8 more
TL;DR: The results demonstrated that all the synthetic aminonaphthoquinones had relevant cytotoxic activity against all human cancer lines used in this experiment and the mechanism of cell growth inhibition and structure–activity relationships remains as a target for future investigations.
Journal ArticleDOI
Biological Evaluation of Pyrazinamide Derivatives as An Anticancer Class
Felipe A. R. Rodrigues,Igor da S. Bomfim,Bruno C. Cavalcanti,Cláudia Pessoa,Alessandra C. Pinheiro,Camilo Henrique da Silva Lima,Marcus V. N. de Souza +6 more
TL;DR: The structure-activity relationship (SAR) analysis indicated that the hydroxyl group located in ortho position is critical for the biological activity of these compounds.