E
Eduardo H. G. da Cruz
Researcher at Universidade Federal de Minas Gerais
Publications - 7
Citations - 298
Eduardo H. G. da Cruz is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Quinone & Peripheral blood mononuclear cell. The author has an hindex of 6, co-authored 7 publications receiving 229 citations. Previous affiliations of Eduardo H. G. da Cruz include Saarland University.
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Journal ArticleDOI
1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones
Eduardo H. G. da Cruz,Caio M.B. Hussene,Gleiston G. Dias,Emilay B. T. Diogo,Isadora M.M. de Melo,Bernardo L. Rodrigues,Mauro G. da Silva,Wagner O. Valença,Celso A. Camara,Ronaldo N. de Oliveira,Yen G. de Paiva,Marília O. F. Goulart,Bruno C. Cavalcanti,Cláudia Pessoa,Eufrânio N. da Silva Júnior +14 more
TL;DR: 1,2,3-Triazole-, arylamino- and thio-substituted naphthoquinones (24, 8, and 2 representatives) showed potent cytotoxicity against different cancer cell lines and may represent promising new lead derivatives for anticancer drug development.
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Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
Eduardo H. G. da Cruz,Molly A. Silvers,Guilherme A. M. Jardim,Jarbas M. Resende,Bruno C. Cavalcanti,Igor da S. Bomfim,Cláudia Pessoa,Carlos A. de Simone,Giancarlo V. Botteselle,Antonio L. Braga,Divya K. Nair,Irishi N. N. Namboothiri,David A. Boothman,Eufrânio N. da Silva Júnior +13 more
TL;DR: Selenium-containing quinone-based 1,2,3-triazoles were synthesized and evaluated against six types of cancer cell lines, and Mechanistic role for NAD(P)H Quinone Oxidoreductase 1 (NQO1) was explained.
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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
Tiago Rodrigues,Markus Werner,Jakob Roth,Eduardo H. G. da Cruz,Marta C. Marques,Padma Akkapeddi,Susana A Lobo,Andreas Koeberle,Francisco Corzana,Eufrânio N. da Silva Júnior,Oliver Werz,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +12 more
TL;DR: Using machine learning, targets were identified for β-lapachone and two new drugs were developed that eliminated the need for H2O2 “spatially aggregating” substance and provided a “smooth” response to EMT.
Journal ArticleDOI
Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions
Guilherme A. M. Jardim,Daisy Jereissati Barbosa Lima,Wagner O. Valença,Bruno C. Cavalcanti,Cláudia Pessoa,Jamal Rafique,Antonio L. Braga,Claus Jacob,Eufrânio N. da Silva Júnior,Eduardo H. G. da Cruz,Eduardo H. G. da Cruz +10 more
TL;DR: Selenium- containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions and stand for a new class of chalcogenium-containing derivatives with potential antitumor activity.
Journal ArticleDOI
Design, synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives
Eduardo H. G. da Cruz,Pedro H. P. R. Carvalho,José R. Corrêa,Diego A. C. Silva,Emilay B. T. Diogo,José Dias de Souza Filho,Bruno C. Cavalcanti,Cláudia Pessoa,Heibbe C. B. de Oliveira,Bruna C. Guido,Demetrio A. da Silva Filho,Brenno A. D. Neto,Eufrânio N. da Silva Júnior +12 more
TL;DR: Two new benzothiadiazole-triazole-linked lapachone derivatives were designed, synthesized and characterized by 1D and 2D NMR spectroscopy, and their photophysical properties were investigated and theoretical calculations (DFT) allowed a better understanding of the derivatives' stability and behaviour.