Igor N. Sergeev

TL;DR: Recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging is summarized.

TL;DR: Results suggest that calpain may take over the role of the major execution protease in apoptosis-like death induced by vitamin D compounds, and these compounds may prove useful in the treatment of tumors resistant to therapeutic agents dependent on the classical caspase cascade.

TL;DR: Regression analysis performed to correlate abundance of species following supplementation with body composition parameters and biomarkers of obesity found an association between a decrease over time in blood glucose and an increase in Lactobacillus abundance, particularly in the synbiotic group.

TL;DR: Targeting this pathway with vitamin D and Ca supplementation could contribute to the prevention and treatment of obesity, however, this potentially effective and affordable approach needs to be evaluated from a safety point of view.

TL;DR: The hypothesis that 1,25(OH)(2)D(3) directly activates this apoptotic pathway by inducing a sustained increase in [Ca(2+)](i) in breast cancer cells is supported, and differences of Ca(2+) regulatory mechanisms in cancer versus normal cells seem to allow 1, 25(OH)D (3) and vitamin D analogs to induce Ca( 2+)-mediated apoptosis selectively in Breast cancer cells.