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Ilaria Ambaglio
Researcher at University of Pavia
Publications - 25
Citations - 3978
Ilaria Ambaglio is an academic researcher from University of Pavia. The author has contributed to research in topics: Myelodysplastic syndromes & Chronic myelomonocytic leukemia. The author has an hindex of 12, co-authored 25 publications receiving 3291 citations.
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Clinical and biological implications of driver mutations in myelodysplastic syndromes.
Elli Papaemmanuil,Moritz Gerstung,Luca Malcovati,Sudhir Tauro,Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Chris J. Yoon,Peter R. Ellis,David C. Wedge,Andrea Pellagatti,Adam Shlien,Michael J. Groves,Simon A. Forbes,Keiran Raine,Jon Hinton,Laura Mudie,Stuart McLaren,Claire Hardy,Calli Latimer,Matteo G. Della Porta,Sarah O’Meara,Ilaria Ambaglio,Anna Gallì,Adam Butler,Gunilla Walldin,Jon W. Teague,Lynn Quek,Alex Sternberg,Alex Sternberg,Carlo Gambacorti-Passerini,Nicholas C.P. Cross,Anthony R. Green,Jacqueline Boultwood,Paresh Vyas,Eva Hellström-Lindberg,David G. Bowen,Mario Cazzola,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +41 more
TL;DR: Analysis of oncogenic mutations in large, well-characterized cohorts of patients illustrates the interconnections between the cancer genome and disease biology, with considerable potential for clinical application.
Journal ArticleDOI
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Luca Malcovati,Elli Papaemmanuil,David T. Bowen,Jacqueline Boultwood,Matteo G. Della Porta,Cristiana Pascutto,Erica Travaglino,Michael J. Groves,Anna L. Godfrey,Ilaria Ambaglio,Anna Gallì,Matteo Claudio Da Via,Simona Conte,Sudhir Tauro,Norene Keenan,Ann Hyslop,Jonathan Hinton,Laura Mudie,James S. Wainscoat,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Eva Hellström-Lindberg,Mario Cazzola +23 more
TL;DR: It is found that SF3B1 mutations are independent predictors of favorable clinical outcome, and their incorporation into stratification systems might improve risk assessment in MDS.
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Clinical significance of somatic mutation in unexplained blood cytopenia
Luca Malcovati,Anna Gallì,Erica Travaglino,Ilaria Ambaglio,Ettore Rizzo,Elisabetta Molteni,Chiara Elena,Virginia Valeria Ferretti,Silvia Catricalà,Elisa Bono,Gabriele Todisco,Antonio Bianchessi,Elisa Rumi,Silvia Zibellini,Daniela Pietra,Emanuela Boveri,Clara Camaschella,Daniela Toniolo,Elli Papaemmanuil,Seishi Ogawa,Mario Cazzola +20 more
TL;DR: Mutation analysis on peripheral blood granulocytes may significantly improve the current diagnostic approach to unexplained cytopenia and more generally the diagnostic accuracy of myeloid neoplasms.
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SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.
Luca Malcovati,Mohsen Karimi,Elli Papaemmanuil,Ilaria Ambaglio,Martin Jädersten,Monika Jansson,Chiara Elena,Anna Gallì,Gunilla Walldin,Matteo G. Della Porta,Klas Raaschou-Jensen,Erica Travaglino,Klaus Kallenbach,Daniela Pietra,Viktor Ljungström,Simona Conte,Emanuela Boveri,Rosangela Invernizzi,Richard Rosenquist,Peter J. Campbell,Mario Cazzola,Eva Hellstrom Lindberg +21 more
TL;DR: SF3B1 mutation identifies a distinct MDS subtype that is unlikely to develop detrimental subclonal mutations and is characterized by indolent clinical course and favorable outcome.
Journal ArticleDOI
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia
Esperanza Such,Ulrich Germing,Luca Malcovati,José Cervera,Andrea Kuendgen,Matteo G. Della Porta,Benet Nomdedeu,Leonor Arenillas,Elisa Luño,Blanca Xicoy,Mari Luz Amigo,David Valcárcel,Kathrin Nachtkamp,Ilaria Ambaglio,Barbara Hildebrandt,Ignacio Lorenzo,Mario Cazzola,Guillermo Sanz +17 more
TL;DR: The prognostic impact of FAB and WHO subtypes are confirmed, the importance of RBC transfusion dependency and cytogenetics is recognized, and a simple and powerful CPSS is offered for accurately assessing prognosis and planning therapy in patients with CMML.