A
Adam Shlien
Researcher at University of Toronto
Publications - 117
Citations - 16729
Adam Shlien is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 38, co-authored 88 publications receiving 13700 citations. Previous affiliations of Adam Shlien include deCODE genetics & Hospital for Sick Children.
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Journal ArticleDOI
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Zachary R. Chalmers,Caitlin F. Connelly,David Fabrizio,Siraj M. Ali,Riley Ennis,Alexa B. Schrock,Brittany Campbell,Adam Shlien,Juliann Chmielecki,Franklin W. Huang,Yuting He,James Sun,Uri Tabori,Mark Kennedy,Daniel S. Lieber,Steven Roels,Jared White,G. Otto,Jeffrey S. Ross,Levi A. Garraway,Levi A. Garraway,Vincent A. Miller,Phillip J. Stephens,Garrett M. Frampton +23 more
TL;DR: Measurements of TMB from comprehensive genomic profiling are strongly reflective of measurements from whole exome sequencing and model that below 0.5 Mb the variance in measurement increases significantly, demonstrating that many disease types have a substantial portion of patients with high TMB who might benefit from immunotherapy.
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A high-resolution recombination map of the human genome
Augustine Kong,Daniel F. Gudbjartsson,Jesus Sainz,Gudrun M. Jonsdottir,Sigurjon A. Gudjonsson,Bjorgvin Richardsson,Sigrun Sigurdardottir,John Barnard,Bjorn Hallbeck,Gisli Masson,Adam Shlien,Stefan T Palsson,Michael L. Frigge,Thorgeir E. Thorgeirsson,Jeffrey R. Gulcher,Kari Stefansson +15 more
TL;DR: Recombination rates are significantly correlated with both cytogenetic structures and sequence and paternal chromosomes show many differences in locations of recombination maxima, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates.
Journal ArticleDOI
Mutational Processes Molding the Genomes of 21 Breast Cancers
Serena Nik-Zainal,Ludmil B. Alexandrov,David C. Wedge,Peter Van Loo,Peter Van Loo,Peter Van Loo,Christopher Greenman,Christopher Greenman,Christopher Greenman,Keiran Raine,David T. Jones,Jonathan Hinton,John D Marshall,Lucy Stebbings,Andrew Menzies,Sancha Martin,Kenric Leung,Lina Chen,Catherine Leroy,Manasa Ramakrishna,Richard Rance,King Wai Lau,Laura Mudie,Ignacio Varela,David J. McBride,Graham R. Bignell,Susanna L. Cooke,Adam Shlien,John Gamble,Ian Whitmore,Mark Maddison,Patrick S. Tarpey,Helen Davies,Elli Papaemmanuil,Philip J. Stephens,Stuart McLaren,Adam Butler,Jon W. Teague,Göran Jönsson,Judy Garber,Daniel P. Silver,Penelope Miron,Aquila Fatima,Sandrine Boyault,Anita Langerød,Andrew Tutt,John W.M. Martens,Samuel Aparicio,Åke Borg,Anne Vincent Salomon,Gilles Thomas,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Michael S. Neuberger,P. Andrew Futreal,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton +59 more
TL;DR: This work generated catalogs of somatic mutation from 21 breast cancers and applied mathematical methods to extract mutational signatures of the underlying processes, finding a remarkable phenomenon of localized hypermutation, termed “kataegis,” was observed.
Journal ArticleDOI
Clinical and biological implications of driver mutations in myelodysplastic syndromes.
Elli Papaemmanuil,Moritz Gerstung,Luca Malcovati,Sudhir Tauro,Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Chris J. Yoon,Peter R. Ellis,David C. Wedge,Andrea Pellagatti,Adam Shlien,Michael J. Groves,Simon A. Forbes,Keiran Raine,Jon Hinton,Laura Mudie,Stuart McLaren,Claire Hardy,Calli Latimer,Matteo G. Della Porta,Sarah O’Meara,Ilaria Ambaglio,Anna Gallì,Adam Butler,Gunilla Walldin,Jon W. Teague,Lynn Quek,Alex Sternberg,Alex Sternberg,Carlo Gambacorti-Passerini,Nicholas C.P. Cross,Anthony R. Green,Jacqueline Boultwood,Paresh Vyas,Eva Hellström-Lindberg,David G. Bowen,Mario Cazzola,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +41 more
TL;DR: Analysis of oncogenic mutations in large, well-characterized cohorts of patients illustrates the interconnections between the cancer genome and disease biology, with considerable potential for clinical application.
Journal ArticleDOI
The Life History of 21 Breast Cancers
Serena Nik-Zainal,Peter Van Loo,Peter Van Loo,Peter Van Loo,David C. Wedge,Ludmil B. Alexandrov,Christopher Greenman,Christopher Greenman,King Wai Lau,Keiran Raine,David T. Jones,John L. Marshall,Manasa Ramakrishna,Adam Shlien,Susanna L. Cooke,Jonathan Hinton,Andrew Menzies,Lucy Stebbings,Catherine Leroy,Mingming Jia,Richard Rance,Laura Mudie,Stephen J. Gamble,Philip J. Stephens,Stuart McLaren,Patrick S. Tarpey,Elli Papaemmanuil,Helen Davies,Ignacio Varela,David J. McBride,Graham R. Bignell,Kenric Leung,Adam Butler,Jon W. Teague,Sancha Martin,Göran Jönsson,Odette Mariani,Sandrine Boyault,Penelope Miron,Aquila Fatima,Anita Langerød,Samuel Aparicio,Andrew Tutt,Anieta M. Sieuwerts,Åke Borg,Gilles Thomas,Anne Vincent Salomon,Andrea L. Richardson,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell +54 more
TL;DR: Algorithms were developed to decipher this narrative and applied them to 21 breast cancers, finding that expansion of the dominant subclone to an appreciable mass may represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.