Zhonghui Xu

TL;DR: It is demonstrated that decidual M1-like macrophages are associated with spontaneous preterm labor and that PPARγ activation via RSG can attenuate the macrophage-mediated proinflammatory response, preventing preterm birth and improving neonatal outcomes.

TL;DR: There are distinct maternal and placental disease pathways, and their interaction influences the clinical presentation of preeclampsia, and the description of these novel pathways in the “molecular phase” of preeClampsia and the identification of their hub molecules may enable timely molecular characterization of patients with distinct phenotypes.

TL;DR: A technique able to detect, quantify, and correct crosstalk effects, as well as identify independent functional modules is described, expected to allow a better understanding of individual experiment results, aswell as a more refined definition of the existing signaling pathways for specific phenotypes.

TL;DR: In this article, the inflammatory-related protein network in the amniotic fluid of patients with preterm labor was characterized by using a multiplex bead array (MAA) assay.

TL;DR: A subset of patients with term clinical chorioamnionitis does not have intra-amniotic infection/inflammation, as demonstrated by elevated AF concentrations of inflammation-related proteins, when compared to women in term labor with uncomplicated pregnancies, suggesting over-diagnosis.