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Immo E. Scheffler
Researcher at University of California, San Diego
Publications - 110
Citations - 6162
Immo E. Scheffler is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Mutant & Chinese hamster. The author has an hindex of 42, co-authored 110 publications receiving 5898 citations. Previous affiliations of Immo E. Scheffler include University of California, Los Angeles & University of California.
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Journal ArticleDOI
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
Jean-Ehrland Ricci,Cristina Muñoz-Pinedo,Patrick Fitzgerald,Béatrice Bailly-Maitre,Guy Perkins,Nagendra Yadava,Immo E. Scheffler,Mark H. Ellisman,Douglas R. Green +8 more
TL;DR: Caspase cleavage of NDUFS1, the 75 kDa subunit of respiratory complex I, is identified as a critical caspase substrate in the mitochondria, required for several mitochondrial changes associated with apoptosis.
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Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation
Valentina Fogal,Adam D. Richardson,Priya Prakash Karmali,Immo E. Scheffler,Jeffrey W. Smith,Erkki Ruoslahti,Erkki Ruoslahti +6 more
TL;DR: It is shown that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis, and suggests that tumor cells use p32 to regulate the balance between OXPHOS and gly colysis.
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A century of mitochondrial research: achievements and perspectives.
TL;DR: Two relatively recent developments have brought mitochondria back into the limelight for a broader audience and the elucidation of the genetic basis for a large number and variety of `mitochondrial diseases' starting in the late 1980s has made studies of mitochondria more relevant to the medical community.
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α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
Lan-Feng Dong,Pauline Low,Jeffrey Clifford Dyason,Xiu-Fang Wang,Lubomir Prochazka,Paul K. Witting,Ruth Freeman,Emma Swettenham,Karel Valis,Ji Liu,Renata Zobalova,Renata Zobalova,Jaroslav Turánek,Doug Spitz,Frederick E. Domann,Immo E. Scheffler,Stephen John Ralph,Jiri Neuzil,Jiri Neuzil +18 more
TL;DR: It is proposed that α-TOS displaces UbQ in CII causing electrons generated by SDH to recombine with molecular oxygen to yield ROS, highlighting CII, a known tumour suppressor, as a novel target for cancer therapy.
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Combined and Individual Mitochondrial HSP60 and HSP10 Expression in Cardiac Myocytes Protects Mitochondrial Function and Prevents Apoptotic Cell Deaths Induced by Simulated Ischemia-Reoxygenation
TL;DR: In this paper, the mitochondrial heat-shock proteins HSP60 and HSP10 form a mitochondrial chaperonin complex, and previous studies have shown that their increased expression exerts a protective effect against ischemic injury when cardiac myocytes are submitted to simulated ischemia.