Inger Andersson

TL;DR: The structure of isopenicillin N synthase (IPNS) complexed with manganese was reported in this paper, which reveals the active site is unusually buried within a "jelly-roll" motif and lined by hydrophobic residues.

TL;DR: A proof-of-concept three-dimensional reconstruction of the giant mimivirus particle from experimentally measured diffraction patterns from an x-ray free-electron laser is presented with a modified version of the expand, maximize and compress algorithm.

TL;DR: It is shown that a beam of aerosolised cyanobacteria can be introduced into the focus of the Linac Coherent Light Source and record diffraction patterns from individual living cells at very low noise levels and at high hit ratios, and it is demonstrated that it is possible torecord diffraction data to nanometer resolution on live cells with X-ray lasers.

TL;DR: In this paper, the Linac Coherent Light Source (LCLS) was used to reconstruct the smallest single biological objects imaged with an X-ray laser using 70,000 diffraction patterns captured over twelve minutes.

TL;DR: Experimental strategies for facilitating the very short and intense pulses from an X-ray laser for the purpose of imaging small bioparticles carries the potential for structure determination at atomic resolution without the need for crystallization.