I
Inna A. Belyantseva
Researcher at National Institutes of Health
Publications - 71
Citations - 7251
Inna A. Belyantseva is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hair cell & Inner ear. The author has an hindex of 41, co-authored 69 publications receiving 6645 citations.
Papers
More filters
Journal ArticleDOI
Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29.
Edward R. Wilcox,Quianna Burton,Sadaf Naz,Saima Riazuddin,Saima Riazuddin,Tenesha N. Smith,Barbara Ploplis,Inna A. Belyantseva,Tamar Ben-Yosef,Nikki A. Liburd,Robert J. Morell,Bechara Kachar,Doris K. Wu,Andrew J. Griffith,Sheikh Riazuddin,Thomas B. Friedman +15 more
TL;DR: In situ hybridization and immunofluorescence studies demonstrated mouse claudin-14 expression in the sensory epithelium of the organ of Corti and demonstrated tight junctions in the cochlear duct.
Journal ArticleDOI
Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.
Federica Di Palma,Ralph H. Holme,Elizabeth C. Bryda,Inna A. Belyantseva,Richard Pellegrino,Bechara Kachar,Karen P. Steel,Konrad Noben-Trauth +7 more
TL;DR: The identification of a new gene mutated in v, called otocadherin, which encodes a very large, single-pass transmembrane protein, that is a critical component of hair bundle formation is reported and it is shown that during early hair-cell differentiation, stereocilia organization is disrupted in v2J homozygotes.
Journal ArticleDOI
Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome
Lorraine A. Everett,Inna A. Belyantseva,Konrad Noben-Trauth,Raquel Cantos,Amy Chen,Sneha I. Thakkar,Shelley Hoogstraten-Miller,Bechara Kachar,Doris K. Wu,Eric D. Green +9 more
TL;DR: The ultrastructural defects seen in the Pds(-/-) mice provide important clues about the mechanisms responsible for the inner-ear pathology associated with PDS mutations.
Journal ArticleDOI
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration
Tamar Ben-Yosef,Inna A. Belyantseva,Thomas L. Saunders,Elizabeth D. Hughes,Kohei Kawamoto,Kohei Kawamoto,Christina M. Van Itallie,Lisa A. Beyer,Karin Halsey,Donald J. Gardner,Edward R. Wilcox,Julia E. Rasmussen,James M. Anderson,David F. Dolan,Andrew Forge,Yehoash Raphael,Sally A. Camper,Thomas B. Friedman +17 more
TL;DR: The data suggest that the TJ complex at the apex of the reticular lamina requires claudin 14 as a cation-restrictive barrier to maintain the proper ionic composition of the fluid surrounding the basolateral surface of outer hair cells.
Journal ArticleDOI
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.
Inna A. Belyantseva,Erich T. Boger,Erich T. Boger,Sadaf Naz,Gregory I. Frolenkov,James R. Sellers,Zubair M. Ahmed,Andrew J. Griffith,Thomas B. Friedman +8 more
TL;DR: It is demonstrated that if green fluorescent protein (GFP)-Myo15a is transfected into hair cells of Myo15ash2 mice, the wild-type pattern of hair bundles is restored by recruitment of endogenous whirlin to the tips of stereocilia.