Showing papers by "Ira Pastan published in 1969"
TL;DR: It is concluded that cyclic AMP is necessary for the normal utilization of a number of carbon sources by E. coli, because it is required for the synthesis of enzymes involved in their metabolism.
190 citations
TL;DR: Transient and catabolite repression of the synthesis of β-galactosidase in E. coli are related phenomena, the result of a decreased intracellular concentration of cyclic AMP.
Abstract: Transient and catabolite repression of the synthesis of β-galactosidase in E. coli are related phenomena, the result of a decreased intracellular concentration of cyclic AMP. The lac operon promoter is the site of action of the cyclic AMP.
157 citations
TL;DR: It is proposed that the intracellular level of cyclic AMP regulates the rate of synthesis of many inducible enzymes in E. coli and other microorganisms and that glucose lowers the rate
155 citations
TL;DR: An adrenocorticotropic hormone (ACTH)-sensitive, steroid-producing mouse adrenal tumor was homogenized and fractionated by differential centrifugation and adenyl cyclase activity that was stimulated by ACTH and by fluoride was purified 10- to 20-fold and localized to particulate fractions.
112 citations
TL;DR: Glucose and α-methyl glucoside repress β-galactosidase synthesis in wild type Escherichia coli and in mutant strains deficient in Enzyme I or in the heat-stable protein of the phosphoenolpyruvate-phosphotransferase system, apparently not required for lactose utilization by E. coli.
88 citations
TL;DR: Cyclic 3',5'-AMP was shown to increase the rate of tryptophanase synthesis in Escherichia coli treated with tris(hydroxymethyl)aminomethane and ethylenediaminetetraacetic acid and induced with tryphan as mentioned in this paper.
84 citations
TL;DR: The antiviral activity of chick interferon was increased by incubation with 10 −2 M cyclic-3′5′-adenosine monophosphate.
65 citations
TL;DR: The results suggest that phospholipids, while not necessary for viral infectivity, do stabilize the structure of the virus.
35 citations
TL;DR: Concentrations of propranolol and phentolamine at concentrations which abolished thyroid-stimulating hormone stimulated glucose oxidation in canine thyroid slices had little effect on the stimulation of glucose oxidation by dibutyryl cyclic 3′,5′-AMP.
Abstract: Thyroid-stimulating hormone increased adenyl cyclase activity in canine and bovine thyroid homogenates. Activation of ade-nyl cyclase was impaired by 3 adrenergic blocking agents, dl-propranolol, d-propranolol and phentolamine, over the range 3−7.5 × 10−4m. The concentrations are approximately 100 times greater than those which produce alpha- or beta-adrenergic blockade. dl-Propranolol and phen-tolamine at 1.5−3.0 × 10−4M impaired thyroid-stimulating hormone stimulation of glucose-l-14C oxidation in canine thyroid slices. A similar effect was seen when the slices were preincubated with propranolol, washed, and then incubated with thyroid-stimulating hormone in the absence of propranolol. Propranolol and phentolamine at concentrations which abolished thyroid-stimulating hormone stimulated glucose oxidation in canine thyroid slices had little effect on the stimulation of glucose oxidation by dibutyryl cyclic 3′,5′-AMP. In bovine thyroids concentrations of propranolol which abolished stimulation of adenyl cy...
29 citations