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Irene Oi-Lin Ng
Researcher at University of Hong Kong
Publications - 441
Citations - 33342
Irene Oi-Lin Ng is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Hepatocellular carcinoma & Cancer. The author has an hindex of 95, co-authored 414 publications receiving 29301 citations. Previous affiliations of Irene Oi-Lin Ng include National University of Singapore & Royal Free Hospital.
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Nuclear factor kappa B–mediated CD47 up‐regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice
Jessica Lo,Eunice Yuen Ting Lau,Rachel Hiu Ha Ching,Bowie Yik Ling Cheng,Mark Kin Fai Ma,Irene Oi-Lin Ng,Terence Kin Wah Lee +6 more
TL;DR: Targeting CD47 in combination with sorafenib is an attractive therapeutic regimen for the treatment of HCC patients because of its synergistic effects on tumor suppression, as compared with sorAFenib and anti‐CD47 Ab alone.
Journal Article
DLC-1 Is Deleted in Primary Hepatocellular Carcinoma and Exerts Inhibitory Effects on the Proliferation of Hepatoma Cell Lines with Deleted DLC-1
TL;DR: The expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma, are investigated and suggest that DLC- 1 may play an important role in hepatocarcinogenesis.
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Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis
Peng Gao,Peng Gao,Carmen Chak-Lui Wong,Edmund Kwok-Kwan Tung,Joyce Man-Fong Lee,Chun-Ming Wong,Irene Oi-Lin Ng +6 more
TL;DR: The results showed that miRNA deregulation was an early event and accumulated throughout the various steps of HBV-associated hepatocarcinogenesis and suggest that miR-145 is a candidate tumor suppressive miRNA and may play an important role in HCC development.
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Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma.
Yi Ren,Hong-Teng Tsui,Ronnie T.P. Poon,Irene Oi-Lin Ng,Zhi Li,Yongxiong Chen,Guoping Jiang,Cecilia Lau,Wun-Ching Yu,Michael Bacher,Sheung Tat Fan +10 more
TL;DR: The results indicated that MIF may act as an autocrine‐acting factor that stimulates angiogenesis and metastasis in HCC by promoting expression of angiogenic factors and migration of tumor cells.
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Surgical lateral clearance in resected rectal carcinomas. A multivariate analysis of clinicopathologic features
Irene Oi-Lin Ng,Ivy S. C. Luk,Siu T. Yuen,Peter W. K. Lau,Christopher J. Pritchett,Matthew Ng,Gar P. Poon,Joana Ho +7 more
TL;DR: The authors examined prospectively 80 resected rectal carcinoma specimens in an attempt to discover a reliable method to detect lateral resection margin involvement by these tumors and to identify pathologic factors that would be prognostically important.