C
Chun-Ming Wong
Researcher at University of Hong Kong
Publications - 98
Citations - 8033
Chun-Ming Wong is an academic researcher from University of Hong Kong. The author has contributed to research in topics: HCCS & Cancer. The author has an hindex of 40, co-authored 86 publications receiving 6277 citations. Previous affiliations of Chun-Ming Wong include Queen Mary University of London & Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
Mengnuo Chen,Lai Wei,Cheuk-Ting Law,Felice Ho-Ching Tsang,Jialing Shen,Carol Lai-Hung Cheng,Long-Hin Tsang,Daniel W.H. Ho,David Kung-Chun Chiu,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +12 more
TL;DR: Methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors and suggest an important mechanism of epigenetic alteration in liver carcinogenesis.
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Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
Wanling Yang,Nan Shen,Dong-Qing Ye,Qiji Liu,Qiji Liu,Yan Zhang,Xiaoxia Qian,Nattiya Hirankarn,Dingge Ying,Hai-Feng Pan,Chi Chiu Mok,Tak Mao Chan,Raymond Woon Sing Wong,KW Lee,Mo Yin Mok,Sik Nin Wong,Alexander Moon Ho Leung,Xiang-Pei Li,Yingyos Avihingsanon,Chun-Ming Wong,Tsz Leung Lee,Marco Ho,Pamela Pui Wah Lee,Yuk Kwan Chang,Philip H. Li,Ruo-Jie Li,Ruo-Jie Li,Lu Zhang,Wilfred Hing Sang Wong,Irene Oi-Lin Ng,Chak Sing Lau,Pak C. Sham,Yu-Lung Lau +32 more
TL;DR: This study confirmed association of the HLA locus, STAT4, TNFSF4, BLK, BANK1, IRF5, and TNFAIP3 with SLE in Asians and found new genetic findings that may help gain a better understanding of the disease and the functions of the genes involved.
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Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong,Daniele M. Gilkes,Huafeng Zhang,Huafeng Zhang,Jasper Chen,Hong Wei,Pallavi Chaturvedi,Stephanie I. Fraley,Chun-Ming Wong,Ui-Soon Khoo,Irene Oi-Lin Ng,Denis Wirtz,Gregg L. Semenza +12 more
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOx-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment.
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Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
TL;DR: The common deregulation of small and long nc RNAs in human HCC is summarized and the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis are reviewed and the potential applications of n cRNAs as diagnostic tools and therapeutic targets are discussed.
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The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2.
Carmen Chak-Lui Wong,Chun-Ming Wong,Edmund Kwok–Kwun Tung,Sandy Leung-Kuen Au,Joyce Man-Fong Lee,Ronnie T.P. Poon,Kwan Man,Irene Oi-Lin Ng +7 more
TL;DR: Overexpression of miR-139 in HCC cells significantly reduced cell migration and invasion in vitro and the incidence and severity of lung metastasis from orthotopic liver tumors in mice.