C
Carmen Chak-Lui Wong
Researcher at University of Hong Kong
Publications - 85
Citations - 7342
Carmen Chak-Lui Wong is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Metastasis & Cancer cell. The author has an hindex of 39, co-authored 71 publications receiving 5351 citations. Previous affiliations of Carmen Chak-Lui Wong include Johns Hopkins University & Li Ka Shing Faculty of Medicine, University of Hong Kong.
Papers
More filters
Journal ArticleDOI
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
Mengnuo Chen,Lai Wei,Cheuk-Ting Law,Felice Ho-Ching Tsang,Jialing Shen,Carol Lai-Hung Cheng,Long-Hin Tsang,Daniel W.H. Ho,David Kung-Chun Chiu,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +12 more
TL;DR: Methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors and suggest an important mechanism of epigenetic alteration in liver carcinogenesis.
Journal ArticleDOI
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong,Daniele M. Gilkes,Huafeng Zhang,Huafeng Zhang,Jasper Chen,Hong Wei,Pallavi Chaturvedi,Stephanie I. Fraley,Chun-Ming Wong,Ui-Soon Khoo,Irene Oi-Lin Ng,Denis Wirtz,Gregg L. Semenza +12 more
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOx-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment.
Journal ArticleDOI
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Huafeng Zhang,Huafeng Zhang,Carmen Chak-Lui Wong,Hong Wei,Daniele M. Gilkes,Preethi Korangath,Pallavi Chaturvedi,Luana Schito,Luana Schito,Jasper Chen,Balaji Krishnamachary,Paul T. Winnard,Venu Raman,L. Zhen,W. A. Mitzner,Saraswati Sukumar,Gregg L. Semenza +16 more
TL;DR: It is demonstrated that inhibition of hypoxia-inducible factor activity in BrCa cells by RNA interference or digoxin treatment inhibits primary tumor growth and also inhibits the metastasis of Br Ca cells to the lungs by blocking the expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM).
Journal ArticleDOI
The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2.
Carmen Chak-Lui Wong,Chun-Ming Wong,Edmund Kwok–Kwun Tung,Sandy Leung-Kuen Au,Joyce Man-Fong Lee,Ronnie T.P. Poon,Kwan Man,Irene Oi-Lin Ng +7 more
TL;DR: Overexpression of miR-139 in HCC cells significantly reduced cell migration and invasion in vitro and the incidence and severity of lung metastasis from orthotopic liver tumors in mice.
Journal ArticleDOI
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.
David Kung-Chun Chiu,Aki Pui-Wah Tse,Iris Ming-Jing Xu,Jane Di Cui,Robin Kit-Ho Lai,Lynna Lan Li,Hui-Yu Koh,Felice Ho-Ching Tsang,Larry Lai Wei,Chun-Ming Wong,Irene Oi-Lin Ng,Carmen Chak-Lui Wong +11 more
TL;DR: It is shown that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promotes the maintenance of MDSCs by preventing their differentiation, and suggests that ENT PD2 may be a good prognostic marker and therapeutic target for cancer patients, especially those receiving immune therapy.